518314-53-9

Basic information

• Product Name: Propanedioic acid, [[(1,1-dimethylethoxy)carbonyl]amino](phenylmethyl)-, diethyl ester
• CAS NO: 518314-53-9
• Molecular Formula: C19H27NO6
• Molecular Weight: 365.426
• Mol File: 518314-53-9.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Propanedioic acid, [[(1,1-dimethylethoxy)carbonyl]amino](phenylmethyl)-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedioic acid, [[(1,1-dimethylethoxy)carbonyl]amino](phenylmethyl)-, diethyl ester(518314-53-9)
• EPA Substance Registry System: Propanedioic acid, [[(1,1-dimethylethoxy)carbonyl]amino](phenylmethyl)-, diethyl ester(518314-53-9)

Safety Data

• Hazardous Substances Data: 518314-53-9(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 102831-44-7 diethyl tert-butoxycarbonylaminomalonate 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 59223-84-6 2-(N-acetylamino)-2-benzylpropanedioic acid ethyl monoester 
• 4522-04-7 ethyl N-{[(1,1-dimethylethyl)oxy]carbonyl}-L-phenylalaninate 
• 176796-27-3 2-tert-butoxycarbonylamino-3-phenyl-propionic acid ethyl ester 
• 1430086-18-2 diethyl amino(benzyl)propanedioate trifluoroacetate 
• 1430104-75-8 (5R)-benzyl-5-(3,4-dihydroisoquinolin-2(1H)-yl-carbonyl)-3-[(1R)-1-phenylethyl]imidazolidine-2,4-dione 
• 1430105-06-8 (5S)-benzyl-5-(3,4-dihydroisoquinolin-2(1H)-yl-carbonyl)-3-[(1R)-1-phenylethyl]imidazolidine-2,4-dione 
• 1430105-05-7 lithium 4-benzyl-2,5-dioxo-1-[(1R)-1-phenylethyl]imidazolidine-4-carboxylate 
• 1430086-19-3 diethyl benzyl({[(1R)-1-phenylethyl]carbamoyl}amino)propanedioate 
• 873566-98-4 diethyl benzyl[[3-benzyloxy-3-oxopropanoyl](tert-butoxycarbonyl)amino]malonate 
• 710350-64-4 L-phenylalanyl-glycine-nitrile 
• 109924-24-5 tert-butyl-(1-((cyanomethyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate 
• 108203-41-4 amino-benzyl-malonic acid 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 

Relevant articles and documents

Amine-Directed Palladium-Catalyzed C?H Halogenation of Phenylalanine Derivatives

An efficient primary-amine-directed, palladium-catalyzed C?H halogenation (X=I, Br, Cl) of phenylalanine derivatives is reported on a range of quaternary amino acid (AA) derivatives thanks to suitable conditions employing trifluoroacetic acid as additive. The extension of this original native functionality-directed ortho-selective halogenation was even demonstrated with the more challenging native phenylalanine as tertiary AA.

Towards a universal organocatalyst for the synthesis of enantioenriched phenylalanine derivatives by enantioselective decarboxylative protonation

Access to enantioenriched non-proteogenic phenylalanine derivatives is described using the enantioselective decarboxylative protonation reaction of amidohemimalonate esters catalysed by various cinchona-based compounds. This study compares the catalytic efficiency as well as the enantioselectivity induced by three types of common organocatalysts, namely thioureas, squaramides and bis-cinchona squaramides. One of the main outcome of this work is the observation of a significant influence of the N-protecting group of the hemimalonate on its interaction with the catalyst. This methodology carried out under mild conditions exhibits good substrate scope and functional group tolerance. A substoichiometric amount of catalyst can also be used in certain cases while affording good yields and selectivities.

MINERALOCORTICOID RECEPTOR ANTAGONISTS

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