51833-83-1

Basic information

• Product Name: C₁₀H₁₂N₂O₃
• CAS NO: 51833-83-1
• Molecular Weight: 208.217
• Mol File: 51833-83-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₀H₁₂N₂O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₀H₁₂N₂O₃(51833-83-1)
• EPA Substance Registry System: C₁₀H₁₂N₂O₃(51833-83-1)

Safety Data

• Hazardous Substances Data: 51833-83-1(Hazardous Substances Data)

Upstream product

• 504-88-1 3-nitropropionic acid 
• 106-49-0 p-toluidine 

Relevant articles and documents

Synthesis of various 3-nitropropionamides as Mycobacterium tuberculosis isocitrate lyase inhibitor

Various 3-nitropropionamides were synthesized and evaluated for in vitro activities against log and starved phase culture of two mycobacterial species and Mycobacterium tuberculosis (MTB) isocitrate lyase (ICL) enzyme inhibition studies. Among 22 compounds, 1-cyclopropyl-7-(3,5-dimethyl-4-(3-nitropropanoyl) piperazin-1-yl)-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (22) was found to be the most active compound in vitro with MICs of 0.16 and 0.04 μM against log- and starved-phase culture of MTB. Compound 22 also showed good enzyme inhibition of MTB ICL with IC50 of 0.10 ± 0.01 μM. The docking studies also confirmed the binding potential of the compounds at the ICL active site.