51867-62-0

Basic information

• Product Name: 3-chloroformyl-7-methoxycoumarin
• Synonyms: 3-chloroformyl-7-methoxycoumarin
• CAS NO: 51867-62-0
• Molecular Formula: C₁₁H₇ClO₄
• Molecular Weight: 238.62
• Mol File: 51867-62-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 407.5°Cat760mmHg
• Flash Point: 182.9°C
• Appearance: /
• Density: 1.444g/cm³
• Vapor Pressure: 7.5E-07mmHg at 25°C
• Refractive Index: 1.591
• CAS DataBase Reference: 3-chloroformyl-7-methoxycoumarin(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloroformyl-7-methoxycoumarin(51867-62-0)
• EPA Substance Registry System: 3-chloroformyl-7-methoxycoumarin(51867-62-0)

Safety Data

• Hazardous Substances Data: 51867-62-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H7ClO4/c1-15-7-3-2-6-4-8(10(12)13)11(14)16-9(6)5-7/h2-5H,1H3

Upstream product

• 20300-59-8 7-methoxycoumarin-3-carboxylic acid 
• 673-22-3 2-Hydroxy-4-methoxybenzaldehyde 
• 6093-71-6 7-hydroxy-2-oxo-2H-chromene-3-carboxylic acid ethyl ester 
• 6093-72-7 7-methoxycoumarin-3-carboxylic acid ethyl ester 
• 95-01-2 2,4-Dihydroxybenzaldehyde 

Downstream Products

• 6093-72-7 7-methoxycoumarin-3-carboxylic acid ethyl ester 
• 97632-67-2 7-methoxycoumarin-3-carbonyl azide 
• 97632-70-7 (7-Methoxy-2-oxo-2H-chromen-3-yl)-carbamic acid cyclohexyl ester 
• 97632-73-0 (7-Methoxy-2-oxo-2H-chromen-3-yl)-carbamic acid benzyl ester 
• 51867-57-3 7-methoxy-3-(5-phenyl-[1,3,4]oxadiazol-2-yl)-chromen-2-one 

Relevant articles and documents

Preparation and application of Sigma-2 fluorescent ligand

The invention mainly relates to synthesis of a series of sigma-2 fluorescent ligands and application of the sigma-2 fluorescent ligands in the fields of pharmacy and medicine, specifically to a series of compounds containing benzopyran structures, wherein the compounds have high affinity activity and selectivity to a sigma-2 receptor, have good affinity activity to the sigma-2 receptor, and have diagnosis and treatment effects on tumor cells, brain cells of patients with Alzheimer's disease, and other cells highly expressing the sigma-2 receptor.

SULFONATE COMPOUND, PHOTOACID GENERATOR, AND RESIN COMPOSITION FOR PHOTOLITHOGRAPHY

Provided are: a non-ionic photoacid generator containing a sulfonate compound having a high photosensitivity to i lines, exhibiting excellent heat-resistance stability, and exhibiting excellent solubility in a hydrophobic material; and a resin composition

Design, synthesis and biological evaluation of coumarin derivatives as novel acetylcholinesterase inhibitors that attenuate H2O2-induced apoptosis in SH-SY5Y cells

A novel series of coumarin derivatives were designed, synthesized and investigated for inhibition of cholinesterase, including acetyl cholinesterase (AChE) and butyrylcholinesterase (BuChE). This biological study showed that these compounds containing piperazine ring had significant inhibition activities on AChE rather than BuChE. Further study suggested that 9x, as one of this kind of structure derivative, showed the strongest inhibition activity on AChE with an IC50 value of 34?nM. Moreover, molecular docking, flow cytometry (FCM), and western blot assay suggested that 9x could induce cytoprotective autophagy to attenuate H2O2-induced cell death in human neuroblastoma SH-SY5Y cells. These findings highlight a new approach for the development of a novel potential neuroprotective compound targeting AChE with autophagy-inducing activity in future Alzheimer's disease (AD) therapy.