519-01-7Relevant articles and documents
Synthesis of Aporphine Analogues via Palladium-Catalyzed Intramolecular Aryl-Aryl Dehydrogenative Coupling
Su, Chen,Xu, Wen-Hua,Guo, Rui-Li,Zhang, Xing-Long,Zhu, Xue-Qing,Gao, Ya-Ru,Wang, Yong-Qiang
, p. 13618 - 13630 (2021/09/28)
Reported herein is an intramolecular dehydrogenative coupling of two inert aryl C-H bonds for the synthesis of aporphine analogues. The process represents a novel tool for the preparation of aporphines via palladiun-catalyzed C-H bond activation. The present reaction is compatible with various functional groups, and the coupling products have been further applied for the synthesis of natural products aporphine and zenkerine.
Synthesis of (±)-aporphine utilizing Pictet-Spengler and intramolecular phenol ortho-arylation reactions
Cuny, Gregory D.
, p. 5167 - 5170 (2007/10/03)
A synthesis of the alkaloid (±)-aporphine is reported. The initial key step of the synthesis involves a Pictet-Spengler cyclization of N-tosyl tyramine with 2-bromophenylacetaldehyde in trifluoroacetic acid. This step was followed by the second strategic