51918-42-4

Basic information

• Product Name: 6,7-dimethoxy-2-isobutanoyl-1,2,3,4-tetrahydroisoquinoline
• CAS NO: 51918-42-4
• Molecular Weight: 277.364
• Mol File: 51918-42-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 6,7-dimethoxy-2-isobutanoyl-1,2,3,4-tetrahydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-dimethoxy-2-isobutanoyl-1,2,3,4-tetrahydroisoquinoline(51918-42-4)
• EPA Substance Registry System: 6,7-dimethoxy-2-isobutanoyl-1,2,3,4-tetrahydroisoquinoline(51918-42-4)

Safety Data

• Hazardous Substances Data: 51918-42-4(Hazardous Substances Data)

Upstream product

• 79-30-1 isobutyryl chloride 
• 493-48-1 (6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline) 

Relevant articles and documents

Synthesis of isoquinoline alkaloid, (±)-salsolidine, using thiazolino[2,3-a]isoquinolinone S-oxide as intermediate

Thiazolino[2,3-a]isoquinolinones have been oxidized to the corresponding S-oxides and their 10b-methyl derivatives desulfurized with Raney nickel to give (±) N-acyl salsolidine. Base-catalyzed hydrolysis of the N-acetyl derivative afforded (±)-salsolidine. C-Methylation reactions of the title heterocyclic system have been investigated throughly. Stereochemistry of the synthesized compounds has been established.