51932-70-8

Basic information

• Product Name: 1H-Indene-4-carboxaldehyde, 2,3-dihydro- (9CI)
• Synonyms: 1H-Indene-4-carboxaldehyde, 2,3-dihydro- (9CI);2,3-DIHYDRO-1H-INDENE-4-CARBALDEHYDE;2,3-dihydro-1H-Indene-4-carboxaldehyde
• CAS NO: 51932-70-8
• Molecular Formula: C₁₀H₁₀O
• Molecular Weight: 146.1858
• Product Categories: ALDEHYDE
• Mol File: 51932-70-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 136 °C(Press: 24 Torr)
• Appearance: /
• Density: 1.122±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1H-Indene-4-carboxaldehyde, 2,3-dihydro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indene-4-carboxaldehyde, 2,3-dihydro- (9CI)(51932-70-8)
• EPA Substance Registry System: 1H-Indene-4-carboxaldehyde, 2,3-dihydro- (9CI)(51932-70-8)

Safety Data

• Hazardous Substances Data: 51932-70-8(Hazardous Substances Data)

Usage

Description

1H-Indene-4-carboxaldehyde, 2,3-dihydro(9CI) is an organic compound with the molecular formula C11H10O. It is a derivative of indene, which is a tricyclic aromatic hydrocarbon. 1H-Indene-4-carboxaldehyde, 2,3-dihydro(9CI) is characterized by its aldehyde functional group and a partially hydrogenated structure, which may contribute to its reactivity and potential applications in various industries.

Uses

Used in Pharmaceutical Industry:
1H-Indene-4-carboxaldehyde, 2,3-dihydro(9CI) is used as a reagent for the preparation of sulfonylurea compounds. These compounds are known for their ability to modulate NLRP (NOD-like receptor family, pyrin domain containing) activity, which plays a crucial role in the regulation of inflammation and immune responses. By targeting NLRP activity, sulfonylurea compounds can be employed in the treatment of various conditions, such as autoimmune disorders and chronic inflammatory diseases.

Upstream product

• 4885-02-3 Dichloromethyl methyl ether 
• 496-11-7 INDANE 
• 201230-82-2 carbon monoxide 
• 116451-83-3 (2E,8E)-deca-2,8-diene-1,10-dial 

Downstream Products

• 4044-54-6 2,3-dihydro-1H-indene-4-carboxylic acid 
• 201486-99-9 (+/-)-Hydroxy-phenyl-(indanyl-⁽⁴⁾)-methan 
• 5385-28-4 indan-4-yl-phenyl ketone 
• 5020-62-2 (4-indanyl)acetic acid 

Relevant articles and documents

Synthesis of aromatic aldehydes by organocatalytic [4+2] and [3+3] cycloaddition of α,β-unsaturated aldehydes

Organocatalytic inter- and intramolecular [4+2] and [3+3] cycloadditions of α,β-unsaturated aldehydes to give polysubstituted aromatic aldehydes are described. High periselectivity for the cycloadditions, with catalyst effects exerted by l-proline and pyrrolidine-HOAc, as well as cocatalyst, additive effects, has been observed.

Optically Active Spiranes, XI: Syntheses of Optically Active Mono to Heptasubstituted 5-Methyl and Ethyl-2,2'-Spirobiindanes and Related Naphthalene Derivatives of Known Chirality and Enantiomeric Purity

Starting from optically active 5,5'-dimethyl, diethyl, and 5-ethyl-5'-methyl-2,2'-spirobiindane as well as from 5'-ethyl-spirobiindane-5-carboxylic ester of known enantiomeric purity and configuration 75 mono to polysubstituted 2,2'-spirobiindanes have been prepared.Amongst these are several compounds with rings anellated in the 6,7 (and 6',7') positions, especially a spirohydrocarbon 4x with orthogonal naphthalene units the circular dichroism of which is reported and discussed.Several mono and disubstituted 5-methyl and ethylindanes (1, 2) have been prepared as models for synthetic transformations in the spirobiindane series.From the molar rotations of symmetrically diacylated 5,5'-dimethyl and diethyl spirobiindanes (4a, 7b, 7c) empirical ligand parameters λ for acetyl and methoxycarbonyl were determined which gave much better results in the calculation of the rotations of appropriate spirobiindanes (with the "shortened polynomal Ansatz") than the λ-values deduced previously from 5,5'-disubstituted spirobiindanes.The significance of these results is briefly discussed. - Keywords: Chirality function; Circular dichroism; Ligand parameters; 5-Methyl and ethylindanes; 1H-NMR spectra