51941-10-7

Basic information

• Product Name: 2-[4-(3-chlorophenyl)piperazin-1-yl]ethanol
• Synonyms: 1-piperazineethanol, 4-(3-chlorophenyl)-
• CAS NO: 51941-10-7
• Molecular Formula: C₁₂H₁₇ClN₂O
• Molecular Weight: 240.7292
• Mol File: 51941-10-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 397.2°C at 760 mmHg
• Flash Point: 194°C
• Density: 1.204g/cm³
• Vapor Pressure: 5.05E-07mmHg at 25°C
• Refractive Index: 1.572
• CAS DataBase Reference: 2-[4-(3-chlorophenyl)piperazin-1-yl]ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[4-(3-chlorophenyl)piperazin-1-yl]ethanol(51941-10-7)
• EPA Substance Registry System: 2-[4-(3-chlorophenyl)piperazin-1-yl]ethanol(51941-10-7)

Safety Data

• Hazardous Substances Data: 51941-10-7(Hazardous Substances Data)

Usage

Chemical class

Piperazine derivatives

Type of compound

Ethanol derivative

Structural feature

Contains a piperazine ring with a 3-chlorophenyl substituent

Pharmacological and biological activities

Interactions with serotonin receptors, potential as a psychoactive substance

Potential medical applications

Treatment of anxiety and depression

Research interest

Medicinal chemistry and drug development fields

Upstream product

• 75-21-8 oxirane 
• 6640-24-0 N-(m-chlorophenyl)piperazine 
• 108-42-9 3-chloro-aniline 
• 584-08-7 potassium carbonate 
• 13078-15-4 1-(3-chlorophenyl)piperazine hydrochloride 
• 540-51-2 2-bromoethanol 

Downstream Products

• 89841-34-9 1-(m-Chlorophenyl)-4-<2-(trimethylsiloxy)ethyl>piperazine 
• 90095-97-9 2-[4-(3-chlorophenyl)-1-piperazinyl]ethyl methyl 4-(2-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 
• 90936-34-8 4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-{2-[4-(3-chloro-phenyl)-piperazin-1-yl]-ethyl} ester 5-methyl ester 
• 90095-96-8 2-[4-(3-chlorophenyl)-1-piperazinyl]ethyl methyl 2,6-dimethyl-4-(3-trifluoromethylphenyl)-1,4-dihydropyridine-3,5-dicarboxylate 
• 89226-67-5 2-<4-(3-chlorophenyl)-1-piperazinyl>ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinecarboxylate 
• 55433-08-4 1-[4-(3-chloro-phenyl)-piperazin-1-yl]-2-(2-nitro-benzoyloxy)-ethane 

Relevant articles and documents

Spiro[pyrrolidine-3,3′-oxindoles] as 5-HT7 receptor ligands

Here we report the design and synthesis of spiro[pyrrolidine-3,3′-oxindole] derivatives representing a novel scaffold of 5-HT7 receptor ligands. The synthesized analogues were validated as low nanomolar ligands showing selectivity in a panel of

Substituted piperazinyl alkyl esters of 2-amino-4-aryl-1,4-dihydro-6-alkyl-3,5-pyridinedicarboxylates

Dihydropyridine derivatives and acid addition salts thereof which are of use as prophylactic or/and therapeutic drugs for cardiovascular diseases, said dihydropyridine derivatives having the formula STR1 wherein R1 is a hydrogen atom or an aryl, R2 and R3 are the same or different and each is an aryl, R4 and R6 are the same or different and each is a lower alkyl, R5 is amino or a lower alkyl, A is an alkylene, X is N or CH and m and n are the same or different and each is 0 or 1, with the proviso that when X is N, R5 is amino.