5196-28-1

Basic information

• Product Name: 5,8-dioxo-5,8-dihydronaphthalen-1-yl acetate
• Synonyms: 1,4-naphthalenedione, 5-(acetyloxy)-; 5,8-Dioxo-5,8-dihydro-1-naphthalenyl acetate; Acetic acid, 5,8-dihydro-5,8-dioxo-1-naphthyl ester
• CAS NO: 5196-28-1
• Molecular Formula: C₁₂H₈O₄
• Molecular Weight: 216.1895
• Mol File: 5196-28-1.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 403.6°C at 760 mmHg
• Flash Point: 183.5°C
• Density: 1.349g/cm³
• Vapor Pressure: 1E-06mmHg at 25°C
• Refractive Index: 1.592
• CAS DataBase Reference: 5,8-dioxo-5,8-dihydronaphthalen-1-yl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 5,8-dioxo-5,8-dihydronaphthalen-1-yl acetate(5196-28-1)
• EPA Substance Registry System: 5,8-dioxo-5,8-dihydronaphthalen-1-yl acetate(5196-28-1)

Safety Data

• Hazardous Substances Data: 5196-28-1(Hazardous Substances Data)

Upstream product

• 605-89-0 1,5-diacetoxynaphthalene 
• 99618-32-3 5,8-Dimethoxy-1-naphthyl ethanoate 
• 481-39-0 5-hydroxynaphtho-1,4-quinone 
• 108-24-7 acetic anhydride 
• 94807-85-9 5-hydroxynaphthalen-1-yl acetate 
• 83-56-7 1,5-dihydroxynaphthalene 
• 91963-30-3 5,8-dimethoxynaphthalen-1-ol 
• 75-36-5 acetyl chloride 
• 64-19-7 acetic acid 

Downstream Products

• 77189-69-6 5-acetoxy-2-bromo-1,4-naphthoquinone 
• 855601-87-5 5-acetoxy-2-p-tolylsulfanyl-[1,4]naphthoquinone 
• 113251-01-7 8-acetoxy-2-(5-dimethylhydrazonofur-2-yl)-1,4-naphthoquinone 
• 68963-22-4 1-hydroxy-6-methylanthracene-9,10-dione 
• 68963-23-5 1-hydroxy-7-methylanthracene-9,10-dione 
• 113809-09-9 1-(N-Carbobenzyloxyamino)-8-acetoxy-1,4,4a,9a-tetrahydro-9,10-anthraquinone 
• 129237-16-7 1-(N-Benzoyl-N-benzylamino)-5-acetoxy-1,4,4a,9a-tetrahydro-9,10-anthraquinone 
• 129-43-1 1-hydroxyanthraquinone 
• 2501-12-4 1-hydroxy-5-nitro-9,10-anthraquinone 
• 2501-14-6 8-nitro-1-hydroxyanthraquinone 
• 481-39-0 5-hydroxynaphtho-1,4-quinone 
• 112740-63-3 5-acetoxy-3(phenylthio)-1,4-naphthoquinone 
• 71700-92-0 5-acetoxy-2-(phenylthio)-1,4-naphthoquinone 
• 117554-11-7 1-methoxy-5-nitro-9,10-anthraquinone 

Relevant articles and documents

Synthesis of 4,8-dimethoxy-1-naphthol via an acetyl migration

Based on acetyl migration, an efficient synthesis of 4,8-dimethoxy-1-naphthol (1) has been achieved with high overall yield. Compared with the reported method, there were several advantages. First, the reaction conditions were mild. Second, the workup of each step was much simpler. Third, juglone as the starting material in the synthesis was readily available. The solvent and reaction temperature greatly influenced the migration process.

Synthesis, biological evaluation, and correlation of cytotoxicity versus redox potential of 1,4-naphthoquinone derivatives

A series of 1,4-naphthoquinone derivatives of lawsone (1), 6-hydroxy-1,4-naphthoquinone (2), and juglone (3) were synthesized by alkylation, acylation, and sulfonylation reactions. The yields of lawsone derivatives 1a-1k (type A), 6-hydroxy-1,4-naphthoqui

Anti-novel coronavirus naphthoquinone compound and medical application thereof

The invention discloses an anti-novel coronavirus naphthoquinone compound and a medical application of the naphthoquinone compound. The structure of the compound is shown as a formula (I), wherein R1is hydrogen, methyl, ethyl, acetyl or propionyl; and R2 is hydrogen, methyl or ethyl. The compound disclosed by the invention has very strong activity of resisting the novel coronavirus, and can be used for inhibiting 3CL hydrolase (3C-like proteinase, 3CLpro) of the 2019-nCoV novel coronavirus. The in-vitro activity determination experiments show that the enzyme inhibition rate of part of the compounds reaches 99% under the concentration of 1 [mu] M. The naphthoquinone compound disclosed by the invention is clear in structure, simple and convenient in preparation method and high in yield, andhas important significance for developing efficient and low-toxicity novel anti-novel coronavirus drugs.