51977-23-2Relevant articles and documents
Immunomodulatory agents: Dioxothiadiazabicyclo[3.3.0]octanes and their 2- spiro derivatives
Refouvelet,Harraga,Nicod,Robert,Seilles,Couquelet,Tronche
, p. 1076 - 1083 (2007/10/02)
A series of 6,8-dioxo-3-thia-1,7-diazabicyclo[3.3.0]octanes and a series of 6,8-dioxo-3-thia-1,7-diazabicyclo[3.3.0]octane 2-spiro derivatives were synthesized from L-(-)-R-cysteine ethyl ester in two steps. The synthetic route involved condensation of the amino acid with an appropriate aldehyde or ketone, then a further condensation of the resultant ethyl thiazolidine-4- carboxylate with an isocyanate or an isothiocyanate. The proliferative response to human lymphocyte mitogen (phytohemagglutinin) was used as a primary screening assay for most of the thiadiazabicyclic compounds in comparison with levamisole. Furthermore, the most active compounds were tested for ability to release soluble receptors (sRIL-2) after mitogenic stimulation of T cells and for ability to activate macrophage oxidative metabolism measured by chemiluminescence. Most compounds were active in all three tests and some showed dose-dependent activity.
REACTION OF 1,3-THIAZOLIDINE-4-CARBOXYLIC AND 1,4-TETRAHYDROTHIAZINE-3-CARBOXYLIC ACID ESTERS WITH ISOCYANATES AND ISOTHIOCYANATES AND STRUCTURES OF THE REACTION PRODUCTS
Eremeev, A. V.,Nurdinov, R.,Polyak, F. D.,Zolotoyabko, R. M.,Mishnev, A. F.,et al.
, p. 1086 - 1091 (2007/10/02)
7-Thia-1,3-diazabicyclooctane-2,4-diones and 7-thia-1,3-diazabicyclononane-2,4-diones, as well as their analogs, were obtained by the reaction of (S)-1,3-thiazolidine-4-carboxylic and 1,4-tetrahydrothiazine-3-carboxylic acid esters with isoc
