51978-97-3

Basic information

• Product Name: (E)-5-(4-chlorostyryl)-3-methyl-4-nitroisoxazole
• Synonyms: (E)-5-(4-chlorostyryl)-3-methyl-4-nitroisoxazole
• CAS NO: 51978-97-3
• Molecular Weight: 264.668
• Mol File: 51978-97-3.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: (E)-5-(4-chlorostyryl)-3-methyl-4-nitroisoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-5-(4-chlorostyryl)-3-methyl-4-nitroisoxazole(51978-97-3)
• EPA Substance Registry System: (E)-5-(4-chlorostyryl)-3-methyl-4-nitroisoxazole(51978-97-3)

Safety Data

• Hazardous Substances Data: 51978-97-3(Hazardous Substances Data)

Upstream product

• 1123-49-5 3,5-dimethyl-4-nitroisoxazole 
• 104-88-1 4-chlorobenzaldehyde 
• 300-87-8 3,5-dimethyl-1,2-oxazole 
• 123-54-6 acetylacetone 

Downstream Products

• 86453-98-7 5-[1,2-Dibromo-2-(4-chloro-phenyl)-ethyl]-3-methyl-4-nitro-isoxazole 
• 132869-22-8 ethyl 2-carbethoxy-3-(4-chlorophenyl)-4-(3-methyl-4-nitroisoxazol-5-yl)butyrate 
• 1021951-84-7 (1R,2S)-1-(4-chlorophenyl)-2-(3-methyl-4-nitro-isoxazol-5-yl)-ethane-1,2-diol 
• 117869-56-4 3-[1-(4-Chloro-phenyl)-2-(3-methyl-4-nitro-isoxazol-5-yl)-ethyl]-7-hydroxy-2-methyl-chromen-4-one 
• 117838-23-0 3-(4-Chloro-phenyl)-2-{1-[(Z)-hydroxyimino]-ethyl}-4-(3-methyl-4-nitro-isoxazol-5-yl)-butyric acid ethyl ester 
• 79510-59-1 3-[1-(4-chlorophenyl)-2-(3-methyl-4-nitroisoxazol-5-yl)ethyl]pentane-2,4-dione 
• 79510-70-6 5-(4-Chloro-phenyl)-3'-methyl-4'-nitro-3-phenyl-4,5-dihydro-[4,5']biisoxazolyl 
• 103806-28-6 2-acetyl-3-(4-chlorophenyl)-4-(3-methyl-4-nitroisoxazol-5-yl)butyric acid ethyl ester 

Relevant articles and documents

Phosphine-Catalyzed [3 + 2] Annulation of Morita-Baylis-Hillman Carbonates with Isoxazole-Based Alkenes

A phosphine-catalyzed [3 + 2] annulation of Morita-Baylis-Hillman (MBH) carbonates with 3-methyl-4-nitro-5-styrylisoxazoles has been developed to afford various multifunctional isoxazoles in moderate to good yields with moderate to excellent diastereoselectivities. With a spirocyclic chiral phosphine as the catalyst, up to 89% ee was obtained.

Tandem grinding reactions involving aldol condensation and Michael addition in sequence for synthesis of 3,4,5-trisubstituted isoxazoles

A one-pot, base-catalyzed, tandem grinding process involving carrying out aldol condensation and Michael addition in sequence to produce 3,4,5-trisubstituted isoxazoles from 3,5-dimethyl-4-nitroisoxazole, aromatic aldehydes and activated methylene compoun

'On water' direct vinylogous Henry (nitroaldol) reactions of 3,5-dimethyl-4-nitroisoxazole with aldehydes and trifluoromethyl ketones

An efficient 'on water'-promoted direct catalytic vinylogous addition of 3,5-dimethyl-4-nitroisoxazole to aldehydes and trifluoromethyl ketones was described, giving Henry (nitroaldol) adducts in excellent yields. The trifluoromethyl tertiary alcohol prod