5198-79-8

Basic information

• Product Name: 2-Chloro-4-formylthiazole
• Synonyms: 2-Chloro-4-formylthiazole;2-CHLOROTHIAZOLE-4-CARBOXALDEHYDE;2-chlorothiazole-4-carbaldehyde;2-chloro-1,3-thiazole-4-carbaldehyde;4-Thiazolecarboxaldehyde,2-chloro-;2-Chloro-1,3-thiazole-4-carboxaldehyde;2-Chloro-4-formyl-1,3-thiazole;2-chloro-4-Thiazolecarboxaldehyde
• CAS NO: 5198-79-8
• Molecular Formula: C₄H₂ClNOS
• Molecular Weight: 147.58278
• Product Categories: Building Blocks;Thiazole
• Mol File: 5198-79-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 278.6 °C at 760 mmHg
• Flash Point: 122.3 °C
• Appearance: /
• Density: 1.541 g/cm³
• Vapor Pressure: 0.00421mmHg at 25°C
• Refractive Index: 1.637
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-Chloro-4-formylthiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-4-formylthiazole(5198-79-8)
• EPA Substance Registry System: 2-Chloro-4-formylthiazole(5198-79-8)

Safety Data

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37
• Hazardous Substances Data: 5198-79-8(Hazardous Substances Data)

Usage

General Description

2-Chloro-4-formylthiazole is a chemical compound that consists of a thiazole ring, a type of heterocyclic compound, substituted with a chlorine atom and a formyl group. Thiazole compounds are often used in the development of pharmaceuticals and agrochemicals due to their range of biological activities. Therefore, 2-Chloro-4-formylthiazole can be used as an intermediate in organic synthesis, particularly in the preparation of various pharmaceuticals. Its molecular formula is C4H2ClNOS and it needs to be handled with care due to its potential to irritate the eyes, skin, and respiratory system.

InChI:InChI=1/C4H2ClNOS/c5-4-6-3(1-7)2-8-4/h1-2H

Upstream product

• 3034-52-4 2-chlorothiazole 
• 68-12-2 N,N-dimethyl-formamide 
• 2591-86-8 N-Formylpiperidine 

Relevant articles and documents

Method for preparing 2-chloro-1,3-thiazole-5-formaldehyde

The invention discloses a method for preparing 2-chloro-1,3-thiazole-5-formaldehyde. The method comprises the following steps: in the presence of lithium diisopropylamide, carrying out a reaction between 2-chlorothiazole shown in (I) and compounds shown in a formula (II) or compounds shown in a formula (IV) under the condition of low temperature to obtain the 2-chloro-1,3-thiazole-5-formaldehyde shown as a formula (III) (The formula is shown in the specification). In the formula (II), substituent groups R1 and R2 are respectively and separately selected from C1 to C4 alkyls; in the formula (IV), X represents C or O element. According to the method disclosed by the invention, the 2-chloro-1,3-thiazole-5-formaldehyde can be prepared by using the lithium diisopropylamide in wider temperaturerange at higher yield; in addition, the method is not reported in literature; the lithium diisopropylamide has better dehydrogenation selectivity and cannot react with carbonyl.