51988-03-5

Basic information

• Product Name: N-(4-methoxyphenyl)-2-phenoxyacetamide
• Synonyms: N-(4-methoxyphenyl)-2-phenoxyacetamide
• CAS NO: 51988-03-5
• Molecular Weight: 257.289
• Mol File: 51988-03-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-(4-methoxyphenyl)-2-phenoxyacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-methoxyphenyl)-2-phenoxyacetamide(51988-03-5)
• EPA Substance Registry System: N-(4-methoxyphenyl)-2-phenoxyacetamide(51988-03-5)

Safety Data

• Hazardous Substances Data: 51988-03-5(Hazardous Substances Data)

Upstream product

• 104-94-9 4-methoxy-aniline 
• 122-59-8 2-phenoxyacetic acid 
• 701-99-5 Phenoxyacetyl chloride 
• 22303-36-2 N-(4-methoxyphenyl)-2-chloroacetamide 
• 108-95-2 phenol 
• 19513-78-1 1-(4-methoxy-phenyl)-2-phenoxy-ethanone 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 100-06-1 1-(4-methoxyphenyl)ethanone 

Downstream Products

• 3598-16-1 2-phenoxyacetic acid sodium salt 
• 104-94-9 4-methoxy-aniline 
• 122-59-8 2-phenoxyacetic acid 
• 1208-86-2 N-(4-methoxyphenyl)phenylamine 

Relevant articles and documents

Synthesis of Some New Acetanilide Derivatives as COX Inhibitors and Assessment of Analgesic/Anti-Inflammatory Activities

The purpose of the present research was to synthesize a new series of acetanilide derivatives that would have analgesic and anti-inflammatory properties in laboratory animals (rats). IR spectroscopy, 1HNMR spectroscopy and Mass spectroscopy wer

Transformation of lignin model compounds to: N -substituted aromatics via Beckmann rearrangement

Here we present the highly effective cleavage of C-C bonds in lignin model compounds for the production of N-substituted aromatics in up to 96% total yield, including benzonitriles and amides, via oxime formation followed by Beckmann rearrangement (BR). The amides could be further hydrolyzed to anilines (>92% yield) and carboxylic acids (>90% yield), respectively. In addition, the employment of a substrate with a γ-OH group will lead to the formation of C-2 monosubstituted oxazole. A one-pot process involving the BR reaction and hydrolysis has also been developed to directly afford an up to 96% total yield of benzonitriles, benzamides, and anilines. This strategy enabled us to successfully apply the BR reaction to the degradation of lignin model compounds to N-functionalized aromatic products under mild conditions.

A convenient preparation of N-alkyl and N-arylamines by smiles rearrangement - Synthesis of analogues of diclofenac

Smiles rearrangement of substituted aryloxyacetamides in which oxygen and nitrogen are separated by COCH2 group has been successful even when the aryloxy ring carries weak or no electron withdrawing group. Earlier reports of such reactions involved either strong electron withdrawing groups or a special catalyst. The diphenylamines thus obtained gave analogues of diclofenac in only one case.