52-43-7 Usage
Description
Allobarbital, a barbiturate derivative, is a pharmaceutical compound known for its anticonvulsant, hypnotic, and analgesic-enhancing properties. It is recognized for its effectiveness in promoting hepatocarcinogenesis and is classified as a controlled substance due to its potential for abuse and dependency.
Uses
Used in Pharmaceutical Industry:
Allobarbital is used as an anticonvulsant for the treatment of various seizure disorders, helping to control and prevent the occurrence of seizures.
Additionally, Allobarbital is used as a hypnotic agent to induce sleep and treat insomnia, particularly in cases where other sedatives have been ineffective.
Furthermore, Allobarbital is used to enhance the activity of analgesic drugs, increasing their effectiveness in managing pain and providing relief to patients.
Lastly, despite its potential risks, Allobarbital is recognized for its role as an effective promoter of hepatocarcinogenesis, contributing to the study and understanding of liver cancer development.
Originator
Allobarbital, Fluorochem Ltd.
Manufacturing Process
To a mixture of 43 parts barbituric acid, 200 parts of water and 5 parts of
cuprous sulfate in 10 parts of water is added 82 parts of allylbromide. Then at
room temperature is added 27 parts of sodium hydroxide (10% aqueous
solution). 5,5-Diallylbarbituric acid is isolated by filtration. After
recrystallization from water 5,5-diallylbarbituric acid has melting polint 169-
170°C.
Therapeutic Function
Sedative, Hypnotic
Check Digit Verification of cas no
The CAS Registry Mumber 52-43-7 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 5 and 2 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 52-43:
(4*5)+(3*2)+(2*4)+(1*3)=37
37 % 10 = 7
So 52-43-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H12N2O3/c1-3-5-11-8(13)7-9(14)12(6-4-2)10(11)15/h3-4H,1-2,5-7H2
52-43-7Relevant articles and documents
Radical Heterocyclization and Heterocyclization Cascades Triggered by Electron Transfer to Amide-Type Carbonyl Compounds
Huang, Huan-Ming,Procter, David J.
supporting information, p. 14262 - 14266 (2017/10/20)
Radical heterocyclizations triggered by electron transfer to amide-type carbonyls, using SmI2-H2O, provide straightforward access to bicyclic heterocyclic scaffolds containing bridgehead nitrogen centers. Furthermore, the first radical heterocyclization cascade triggered by reduction of amide-type carbonyls delivers novel, complex tetracyclic architectures containing five contiguous stereocenters with excellent diastereocontrol.
Spiro-annulation of barbituric acid derivatives and its analogs by ring-closing metathesis reaction
Kotha, Sambasivarao,Deb, Ashoke Chandra,Kumar, Ramanatham Vinod
, p. 1039 - 1043 (2007/10/03)
Barbituric acid 1 and related β-dicarbonyl compounds were dialkenylated under the phase-transfer catalyst [e.g., benzyltriethylammonium chloride (BTEAC)] conditions to generate the diallylated products. These diallylated products were subjected to the ring-closing metathesis (RCM) reaction to deliver the corresponding spiro-annulated derivatives.
This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.