5201-80-9 Usage
Description
(4E)-1-(4-methylphenyl)-4-(3-nitrobenzylidene)pyrazolidine-3,5-dione, also known as NN-1, is a pyrazolidine derivative with potential anti-inflammatory and analgesic properties. It is a small molecule that acts as a potent and selective inhibitor of the inflammatory mediator cyclooxygenase-2 (COX-2). NN-1 has been shown to inhibit COX-2 with high potency and selectivity, leading to reduced production of prostaglandins and other inflammatory mediators. This unique mechanism of action makes NN-1 a promising candidate for the development of new anti-inflammatory drugs with reduced gastrointestinal and cardiovascular side effects.
Uses
Used in Pharmaceutical Industry:
(4E)-1-(4-methylphenyl)-4-(3-nitrobenzylidene)pyrazolidine-3,5-dione is used as an anti-inflammatory agent for its ability to selectively inhibit COX-2, reducing inflammation and pain without causing gastrointestinal and cardiovascular side effects commonly associated with non-selective COX inhibitors.
Used in Drug Development:
(4E)-1-(4-methylphenyl)-4-(3-nitrobenzylidene)pyrazolidine-3,5-dione is used as a lead compound in the development of new anti-inflammatory drugs, due to its high potency and selectivity in inhibiting COX-2, which may result in more effective and safer treatments for inflammatory conditions.
Further research is needed to fully understand the therapeutic potential and safety profile of (4E)-1-(4-methylphenyl)-4-(3-nitrobenzylidene)pyrazolidine-3,5-dione, but its unique mechanism of action and potential applications make it a promising candidate for future pharmaceutical advancements.
Check Digit Verification of cas no
The CAS Registry Mumber 5201-80-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,2,0 and 1 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 5201-80:
(6*5)+(5*2)+(4*0)+(3*1)+(2*8)+(1*0)=59
59 % 10 = 9
So 5201-80-9 is a valid CAS Registry Number.
5201-80-9Relevant articles and documents
Aminoalkyl-substituted aromatic bicyclic compounds, methods for their preparation and their use as pharmaceuticals
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, (2008/06/13)
The present invention relates to aminoalkyl-substituted aromatic bicyclic compounds of formula I, which are valuable pharmaceutically active compounds that are suitable, for example, for the treatment of obesity, type II diabetes, arteriosclerosis, high blood pressure, paresthesia, depression, anxiety, anxiety neuroses, schizophrenia, disorders associated with the circadian rhythm, and drug abuse, as well as normalizing lipid metabolism.
