52017-46-6 Usage
Description
Butyl Methanethiosulfonate (BMTS) is a clear, colorless liquid that is known for its specific and rapid reaction with thiols to form mixed disulfides. This unique property makes it a valuable tool in the study of various biological systems and processes.
Uses
Used in Pharmaceutical Research:
Butyl Methanethiosulfonate is used as a research tool for probing the structures of important receptor channels and transport proteins. Its ability to form mixed disulfides with thiols allows researchers to investigate the function and structure of these biological targets in greater detail.
Used in the Study of ACh Receptor Channel:
In the field of neurobiology, Butyl Methanethiosulfonate is used as a structural probe for the ACh (acetylcholine) receptor channel. This application helps researchers understand the mechanisms of neurotransmission and the role of ACh receptors in various physiological processes.
Used in the Study of GABA Receptor Channel:
Butyl Methanethiosulfonate is also used as a structural probe for the GABA (gamma-aminobutyric acid) receptor channel. This application aids in the study of inhibitory neurotransmission and the role of GABA receptors in maintaining the balance of neuronal activity.
Used in the Study of Lactose Permease:
In the field of biochemistry, Butyl Methanethiosulfonate is used as a structural probe for lactose permease, a transport protein responsible for the facilitated diffusion of lactose across cell membranes. This application helps researchers understand the molecular mechanisms of substrate binding and transport in membrane proteins.
Overall, Butyl Methanethiosulfonate is a versatile and valuable compound in the fields of pharmaceutical research, neurobiology, and biochemistry, due to its unique chemical properties and its ability to provide insights into the structures and functions of various biological systems.
Check Digit Verification of cas no
The CAS Registry Mumber 52017-46-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,0,1 and 7 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 52017-46:
(7*5)+(6*2)+(5*0)+(4*1)+(3*7)+(2*4)+(1*6)=86
86 % 10 = 6
So 52017-46-6 is a valid CAS Registry Number.
InChI:InChI=1/C5H12O2S2/c1-3-4-5-8-9(2,6)7/h3-5H2,1-2H3
52017-46-6Relevant articles and documents
Sustainable three-component synthesis of isothioureas from isocyanides, thiosulfonates, and amines
Mampuys, Pieter,Zhu, Yanping,Vlaar, Tj?stil,Ruijter, Eelco,Orru, Romano V. A.,Maes, Bert U. W.
supporting information, p. 12849 - 12854 (2016/02/18)
Multiple applications of isothioureas as fine chemicals (or their precursors) are known, but a general sustainable method for their synthesis was hitherto unavailable. We report a novel general approach towards S-alkyl and S-aryl isothioureas through a copper(I)-catalyzed three-component reaction between amines, isocyanides, and thiosulfonates. The formal synthesis of a superpotent sweetener further illustrates the applicability of our method. Safety first! A direct synthesis of isothioureas by a copper-catalyzed three-component reaction from readily available substrates (see scheme) avoids the toxic, flammable, and highly reactive reagents required in classical approaches. The reaction also enables the straightforward synthesis of S-aryl isothioureas, which are difficult to obtain by other methods.
