5202-86-8

Basic information

• Product Name: 4-CHLORO-2-METHYLACETANILIDE
• Synonyms: 4'-CHLORO-2'-METHYLACETANILIDE;4-CHLORO-2-METHYLACETANILIDE;N-(4-chloro-2-methylphenyl)acetamide;4-Chloro-2-methylacetanilide, 95+%;4-Chloro-2-methylacetanilide 95%
• CAS NO: 5202-86-8
• Molecular Formula: C₉H₁₀ClNO
• Molecular Weight: 183.63
• EINECS: 225-991-9
• Mol File: 5202-86-8.mol
• Article Data: 9

Chemical Properties

• Melting Point: 136 °C
• Boiling Point: 324.3 °C at 760 mmHg
• Flash Point: 149.9 °C
• Appearance: /
• Density: 1.218 g/cm³
• Vapor Pressure: 0.000248mmHg at 25°C
• Refractive Index: 1.581
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), Water (Slightly)
• BRN: 2087943
• CAS DataBase Reference: 4-CHLORO-2-METHYLACETANILIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-2-METHYLACETANILIDE(5202-86-8)
• EPA Substance Registry System: 4-CHLORO-2-METHYLACETANILIDE(5202-86-8)

Safety Data

• Statements: R22:Harmful if swallowed.
• Safety Statements: S22:Do not inhale dust.; S36/37:Wear suitable protective clothing and gloves.
• Hazardous Substances Data: 5202-86-8(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Synthetic Communications, 21, p. 1917, 1991 DOI: 10.1080/00397919108021782

InChI:InChI=1/C9H10ClNO/c1-6-5-8(10)3-4-9(6)11-7(2)12/h3-5H,1-2H3,(H,11,12)

Upstream product

• 507-40-4 tert-butylhypochlorite 
• 120-66-1 N-(2-methylphenyl)acetamide 
• 5152-76-1 N-chloro-2'-methylacetanilide 
• 75-36-5 acetyl chloride 
• 95-69-2 4-chloro-2-methylbenzeneamine 
• 75-15-0 carbon disulfide 
• 7791-25-5 sulfuryl dichloride 
• 7647-01-0 hydrogenchloride 
• 7732-18-5 water 
• 64-19-7 acetic acid 
• 7782-50-5 chlorine 
• 88-72-2 1-methyl-2-nitrobenzene 
• 108-24-7 acetic anhydride 
• 95-53-4 o-toluidine 

Downstream Products

• 62790-50-5 4-chloro-2-methyl-6-nitrophenylamine 
• 61655-97-8 2,4-dichloro-6-methylacetanilide 
• 230303-11-4 p,N-dichloro-2'-methylacetanilide 
• 635-21-2 5-chloroanthranilic acid 
• 5202-87-9 2-acetamido-5-chlorobenzoic acid 
• 19655-50-6 6-chloro-8-methylquinoline 
• 6164-98-3 chlordimeform 
• 30273-00-8 2-methyl-4,6-dichloroaniline 
• 857616-95-6 acetic acid-(4-chloro-2-methyl-6-nitro-anilide) 
• 27527-95-3 6-chloro-8-methyl-5-nitroquinoline 
• 34649-00-8 N-(2-methyl-4-chloro-5-nitrophenyl)acetamide 
• 34649-01-9 2-acetylamino-5-chloro-4-nitrobenzoic acid 
• 34649-02-0 2-amino-5-chloro-4-nitrobenzoic acid 

Relevant articles and documents

Method for synthesizing P-chloroO-toluidine

The invention discloses a method for synthesizing p-chloroo-toluidine, which comprises the following steps: synthesizing o-toluidine and a protective agent in an organic solvent to obtain an amino-protected intermediate. The amino protected intermediate is added into hydrochloric acid, an oxidant is added for chlorination reaction, and a chlorination product is obtained. The chlorinated product is removed and the amino protecting group is removed to give p-chloroo-toluidine. The method for synthesizing p-chloroo-toluidine provided by the invention is high in yield, simple to operate, less in three wastes, high in product content and good in quality, and can be suitable for industrial mass production.

Chemoselective reduction of nitroarenes, N-acetylation of arylamines, and one-pot reductive acetylation of nitroarenes using carbon-supported palladium catalytic system in water

Developing and/or modifying fundamental chemical reactions using chemical industry-favorite heterogeneous recoverable catalytic systems in the water solvent is very important. In this paper, we developed convenient, green, and efficient approaches for the chemoselective reduction of nitroarenes, N-acetylation of arylamines, and one-pot reductive acetylation of nitroarenes in the presence of the recoverable heterogeneous carbon-supported palladium (Pd/C) catalytic system in water. The utilize of the simple, effective, and recoverable catalyst and also using of water as an entirely green solvent along with relatively short reaction times and good-to-excellent yields of the desired products are some of the noticeable features of the presented synthetic protocols. Graphic abstract: [Figure not available: see fulltext.].

Co3O4 nanoparticles prepared by oxidative precipitation method: an efficient and reusable heterogeneous catalyst for N-formylation of amines

Abstract: N-formylation of different amines was carried out with formic acid in the presence of the Co3O4 nanoparticles as an efficient, stable heterogeneous catalyst to give the corresponding formamides under solvent-free conditions. This method has advantages over the reported methods such as high yields, mild conditions, easy work-up and short reaction times. The catalyst was characterized by different techniques such as XRD, SEM and FT-IR spectroscopy. Graphical Abstract: [Figure not available: see fulltext.]