5204-87-5 Usage
Description
Calendic acid, also known as 8E,10E,12Z-conjugated linolenic acid, is a type of conjugated linolenic acid with three double bonds located at positions 8, 10, and 12. It is a bioactive compound that has been found to possess various beneficial properties for human health.
Uses
Used in Pharmaceutical Industry:
Calendic acid is used as a pharmaceutical agent for its potential anti-inflammatory, anti-cancer, and anti-atherosclerotic properties. It has been shown to modulate various cellular signaling pathways, leading to the inhibition of tumor growth and progression in certain types of cancer.
Used in Nutraceutical Industry:
Calendic acid is used as a nutraceutical ingredient due to its potential health benefits, such as improving cardiovascular health, reducing inflammation, and supporting immune function. It can be incorporated into dietary supplements and functional foods to provide these benefits to consumers.
Used in Cosmetic Industry:
In the cosmetic industry, calendic acid is used as an active ingredient in skincare products for its potential anti-aging, anti-inflammatory, and skin-protective properties. It may help to improve skin elasticity, reduce the appearance of fine lines and wrinkles, and protect the skin from environmental stressors.
Used in Research and Development:
Calendic acid is also used in research and development for its potential applications in various fields, such as drug discovery, functional food development, and cosmetic formulation. Scientists are continually exploring the properties and potential benefits of this compound to develop new products and therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 5204-87-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,2,0 and 4 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 5204-87:
(6*5)+(5*2)+(4*0)+(3*4)+(2*8)+(1*7)=75
75 % 10 = 5
So 5204-87-5 is a valid CAS Registry Number.
InChI:InChI=1/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-11H,2-5,12-17H2,1H3,(H,19,20)/b7-6-,9-8+,11-10+
5204-87-5Relevant articles and documents
The Biosynthesis of Calendic Acid, Octadeca-(8E,10E,12Z)-trienoic Acid, by Developing Marigold Seeds: Origins of (E,E,Z) and (Z,E,Z) conjugated Triene Acids in Higher Plants
Crombie, Leslie,Holloway, Stephen J.
, p. 2425 - 2434 (2007/10/02)
Using an homogenate of marigold seeds, gathered 15 days after flower-drop, linoleic acid and oleic acid were incorporated into calendic acid with little randomisation of the label. Linolenic acid was not incorporated.Despite requiring 12,13-dehydrogenation to form linoleic acid, the putative precursor, oleic acid was better incorporated than administered linoleic acid.Stearic acid, requiring both 12,13- and 9,10-dehydrogenation, was a poor precursor.The results of a series of doublelabelling experiments support and supplement these conclusions. Octadec-9-enoic acid was synthesised and employed in a mass-spectral experiment to show that conversion into calendic acid involves loss of two deuterium and two hydrogen atoms (deuterium at C-16 and C-17 was introduced for loading purposes only, in order to increase the sensitivity of the experiment).Taken with -labelling work, the experiment indicates that during conversion of linoleic acid into calendic acid, there is no loss of the labelled hydrogens at C-9, -10, -12, or -13, but loss of hydrogen from each of C-8 and C-11. (9S)-Hydroxyoctadeca-(10E,12Z)-dienoic acid (α-dimorphecolic acid) was isolated and converted into (R/S)-hydroxy- and hydroperoxy-octadeca-(10E,12Z)-dienoic acids.Neither labelled specimen was converted into calendic acid by marigold seed homogenate.Abstraction of a hydrogen atom from C-11 of linoleic acid is viewed as giving an (E)-allylic radical which, as in lipoxygenase reactions, can be trapped by oxygen at C-9, thus providing a source of α-dimorphecolic acid, a minor component of marigold seed oil.However, this hydroxyacid is apparently a terminus rather than an intermediate for calendic acid.Formation of the latter seems best accounted for by formal loss of a hydrogen atom from C-8 of the (E)-allylic redical.The general position relating to the formation of (E,E,Z) and (Z,E,Z)-trienes is summarised.
