5205-42-5

Basic information

• Product Name: N-[2-(2-benzamidoethyldisulfanyl)ethyl]benzamide
• CAS NO: 5205-42-5
• Molecular Formula: C₁₈H₂₀N₂O₂S₂
• Molecular Weight: 360.501
• Mol File: 5205-42-5.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: N-[2-(2-benzamidoethyldisulfanyl)ethyl]benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-(2-benzamidoethyldisulfanyl)ethyl]benzamide(5205-42-5)
• EPA Substance Registry System: N-[2-(2-benzamidoethyldisulfanyl)ethyl]benzamide(5205-42-5)

Safety Data

• Hazardous Substances Data: 5205-42-5(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 60-23-1 Cysteamine 
• 65-85-0 benzoic acid 
• 73721-89-8 N-(2-Sulfanylethyl)benzamide 
• 90-02-8 salicylaldehyde 
• 56-17-7 cystamine dihydrochioride 
• 51-85-4 2,2'-dithio-bis[ethylamine] 
• 2722-34-1 2-phenylthiazoline 
• 2937-53-3 2-aminoethylthiosulfonic acid 
• 99071-70-2 N-(2-thiocyanato-ethyl)-benzamide 
• 18838-10-3 N-(2-hydroxyethyl)-benzamide 

Downstream Products

• 29824-06-4 bis-(2-benzylamino-ethyl)-disulfide 
• 67619-92-5 N-benzoyl-2-aminoethanesulfonic acid 
• 99855-18-2 1-acetylsulfanyl-2-benzoylamino-ethane 
• 92555-37-8 N-[2-(2,4-dinitro-phenylsulfanyl)-ethyl]-benzamide 
• 6474-42-6 N,N'-dibenzoylselenocystamine 
• 101292-95-9 N-(2-benzylsulfanyl-ethyl)-benzamide 
• 55065-04-8 S-2-(N-benzoylamino)ethyl benzothioathe 
• 73721-89-8 N-(2-Sulfanylethyl)benzamide 
• 51-85-4 2,2'-dithio-bis[ethylamine] 
• 2722-34-1 2-phenylthiazoline 

Relevant articles and documents

Oxidation of Disulfides to Taurine and Sulfanilic Acid Derivatives

Taurine (2-aminoethanesulfonic acid) is a representative substructure in biologically active compounds, but can raise difficulties in direct coupling reactions. In this study, the synthesis of taurine-derived sulfonic acids and analogous aromatic sulfonic

The use of phosphonium anhydrides for the synthesis of 2-oxazolines, 2-thiazolines and 2-dihydrooxazine under mild conditions

β-Hydroxy amides 6 and 7 were treated with triphenylphosphonium anhydride trifluoromethane sulfonate (3), or the cyclic analogue 4, to generate 2-oxazolines 5 and 8 under mild conditions. The reaction was optimised by examining the number of equivalents of reagents 3 or 4, or diisopropylethyl amine required to best effect cyclisation. The effects of altering the reaction temperature, reaction time, concentration, solvent, and addition rate also were investigated. However, it was found that use of a trityl group to block reaction at the hydroxyl or thiol group of the starting amides, and subsequent in situ detritylation, in the absence of base, led to greatly improved yields. Reagent 4 offered significant advantages in the purification of products and was used to dehydrate a range of trityl derivatives to form simple oxazolines, thiazolines, and a dihydro-1,3-oxazine, in high yield (85-99%), as well as a tetrahydro-1,3-oxazepine (31%).

Zeolite-catalyzed simple synthesis of different heterocyclic rings, part 2

A simple and environmentally friendly synthesis was developed for the preparation of 2-arylimidazoline derivatives and 2-arylbenzoxazole derivatives using a small pore size zeolite. The similar reaction was not applicable to the preparation of the sulfur-containing analogs cysteamine or 2-aminothiophenol, probably because of a disadvantageous reaction between the zeolite and the thio compound.