52059-69-5

Basic information

• Product Name: 5-(4-iodo-phenyl)-[1,3,4]oxathiazol-2-one
• Synonyms: 5-(4-iodo-phenyl)-[1,3,4]oxathiazol-2-one
• CAS NO: 52059-69-5
• Molecular Weight: 305.096
• Mol File: 52059-69-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(4-iodo-phenyl)-[1,3,4]oxathiazol-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-iodo-phenyl)-[1,3,4]oxathiazol-2-one(52059-69-5)
• EPA Substance Registry System: 5-(4-iodo-phenyl)-[1,3,4]oxathiazol-2-one(52059-69-5)

Safety Data

• Hazardous Substances Data: 52059-69-5(Hazardous Substances Data)

Upstream product

• 3956-07-8 4-iodobenzamide 
• 2757-23-5 chloro(chlorosulfanyl)methanone 

Relevant articles and documents

Discovery of an Isothiazole-Based Phenylpropanoic Acid GPR120 Agonist as a Development Candidate for Type 2 Diabetes

We have discovered a novel series of isothiazole-based phenylpropanoic acids as GPR120 agonists. Extensive structure-activity relationship studies led to the discovery of a potent GPR120 agonist 4x, which displayed good EC50 values in both calcium and β-arrestin assays. It also presented good pharmaceutical properties and a favorable PK profile. Moreover, it demonstrated in vivo antidiabetic activity in C57BL/6 DIO mice. Studies in WT and knockout DIO mice showed that it improved glucose handling during an OGTT via GPR120. Overall, 4x possessed promising antidiabetic effect and good safety profile to be a development candidate.