52063-43-1

Basic information

• Product Name: 5-(4-bromophenyl)-3-methylisoxazole
• Synonyms: 5-(4-bromophenyl)-3-methylisoxazole
• CAS NO: 52063-43-1
• Molecular Formula: C₁₀H₈BrNO
• Molecular Weight: 238.08062
• Mol File: 52063-43-1.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(4-bromophenyl)-3-methylisoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-bromophenyl)-3-methylisoxazole(52063-43-1)
• EPA Substance Registry System: 5-(4-bromophenyl)-3-methylisoxazole(52063-43-1)

Safety Data

• Hazardous Substances Data: 52063-43-1(Hazardous Substances Data)

Usage

Description

5-(4-bromophenyl)-3-methylisoxazole is an organic compound that features a bromophenyl group attached to an isoxazole ring with a methyl group at the 3-position. 5-(4-bromophenyl)-3-methylisoxazole is known for its potential applications in the pharmaceutical industry due to its unique structural properties.

Uses

Used in Pharmaceutical Industry:
5-(4-bromophenyl)-3-methylisoxazole is used as a key intermediate compound in the synthesis of isoxazole-based therapeutic agents. Its application is particularly relevant in the development of Lysophosphatidic Acid (LPA) receptor antagonists, which are important for various medical treatments.
As a therapeutic agent, 5-(4-bromophenyl)-3-methylisoxazole and its derivatives have the potential to modulate LPA receptor signaling pathways, which are involved in various cellular processes, including cell proliferation, migration, and survival. By targeting these receptors, LPA receptor antagonists can be used to treat a range of conditions, such as cancer, fibrosis, and cardiovascular diseases.

Upstream product

• 619-42-1 4-methoxycarbonylphenyl bromide 
• 127-06-0 acetone oxime 
• 178261-64-8 1-(4-bromophenyl)-3-(dimethylamino)but-2-en-1-one 
• 99-90-1 para-bromoacetophenone 
• 378186-96-0 1-(4-bromophenyl)-2,3-butadien-1-one 

Downstream Products

• 1056456-11-1 3-methyl-5-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)isoxazole 

Relevant articles and documents

Monohydrochloride Assisted Synthesis of Functionalized Isoxazoles and Pyrazoles from Allenic Ketones: First Synthesis of (Z)-2-Methyl-7H-benzo[b]pyrazolo[5,1-d][1,5]oxazocines

A facile hydrochloride promoted regioselective synthesis of isoxazoles and pyrazoles from 1,2-allenic ketones is reported. The reaction has been scaled up to gram scale. A direct 8-endo dig ring annulations towards the first synthesis of (Z)-2-methyl-7H-b

Clean and efficient synthesis of isoxazole derivatives in aqueous media

A series of 5-arylisoxazole derivatives were synthesized via the reaction of 3-(dimethyl-amino)-1-arylprop-2-en-1-ones with hydroxylamine hydrochloride in aqueous media without using any catalyst. This method has the advantages of easier work-up, mild rea

NOVEL PHENYLPROPIONIC ACID DERIVATIVES AS PEROXISOME PROLIFERATOR-ACTIVATED GAMMA RECEPTOR MODULATORS, METHOD OF THE SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention provides a novel phenylpropionic acid derivative and a PPAR-γ modulator comprising the same as an active ingredient. The phenylpropionic acid derivative of the present invention has modulatory action on function of PPAR-γ and then exhibits hypoglycemic, hypolipidemic and insulin resistance-reducing effects on PPAR-mediated diseases or disorders. Therefore, the present invention is prophylactically or therapeutically effective for diabetes and metabolic diseases.