52073-64-0

Basic information

• Product Name: Ethanol, 2-[3-(trifluoromethyl)phenoxy]-
• CAS NO: 52073-64-0
• Molecular Formula: C9H9F3O2
• Molecular Weight: 206.164
• Mol File: 52073-64-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Ethanol, 2-[3-(trifluoromethyl)phenoxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanol, 2-[3-(trifluoromethyl)phenoxy]-(52073-64-0)
• EPA Substance Registry System: Ethanol, 2-[3-(trifluoromethyl)phenoxy]-(52073-64-0)

Safety Data

• Hazardous Substances Data: 52073-64-0(Hazardous Substances Data)

Upstream product

• 98-17-9 3-Trifluoromethylphenol 
• 540-51-2 2-bromoethanol 
• 588-26-1 methyl 2-[3-(trifluoromethyl)phenoxy]acetate 
• 107-07-3 2-chloro-ethanol 

Downstream Products

• 1303528-51-9 1-{[2-(3-trifluoromethylphenoxy)ethoxy]methyl}-3-aminocarbonylpyridinium chloride 

Relevant articles and documents

Selective C-F Functionalization of Unactivated Trifluoromethylarenes

Fluorinated organic molecules are pervasive within the pharmaceutical and agrochemical industries due to the range of structural and physicochemical properties that fluorine imparts. Currently, the most abundant methods for the synthesis of the aryl-CF2 functionality have relied on the deoxyfluorination of ketones and aldehydes using expensive and poorly atom economical reagents. Here, we report a general method for the synthesis of aryl-CF2R and aryl-CF2H compounds through activation of the corresponding trifluoromethyl arene precursors. This strategy is enabled by an endergonic electron transfer event that provides access to arene radical anions that lie outside of the catalyst reduction potential. Fragmentation of these reactive intermediates delivers difluorobenzylic radicals that can be intercepted by abundant alkene feedstocks or a hydrogen atom to provide a diverse array of difluoalkylaromatics.

Structure-activity relationship studies and sleep-promoting activity of novel 1-chloro-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine derivatives as dual orexin receptor antagonists. Part 2

Replacement of the dimethoxyphenyl moiety in the core skeleton of almorexant by appropriately substituted imidazoles afforded novel 1-chloro-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine derivatives as potent dual orexin receptor antagonists. We describe in th

5,6,7,8-TETRAHYDRO-IMIDAZO[1,5-A]PYRAZINE DERIVATIVES

The invention relates to 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine derivatives of formula (I),wherein X represents CH2 or O; R1 represents a phenyl group, which group is independently mono-, di-, or tri-substituted wherein the substituents are independently selected from the group consisting of (C1-4)alkyl, (C1-4)alkoxy, halogen, cyano, trifluoromethoxy and trifluoromethyl; R2 represents (C1-4)alkyl, (C1-4)alkoxy, (C2-4)alkenyl, halogen, cyano, hydroxymethyl, trifluoromethyl, C(O)NR5R6 or cyclopropyl; R3 represents (C1-4)alkyl, (C1-4)alkoxy-methyl or halogen; R4 represents (C1-4)alkyl; R5 represents hydrogen or (C1-4)alkyl; and R6 represents hydrogen or (C1-4)alkyl. The invention also relates to pharmaceutically acceptable salts of such compounds; and to the use of such compounds as medicaments; especially as orexin receptor antagonists.