52095-18-8

Basic information

• Product Name: 3,5-diMethyl-2-nitrobenzoic acid
• Synonyms: 3,5-diMethyl-2-nitrobenzoic acid
• CAS NO: 52095-18-8
• Molecular Formula: C₉H₉NO₄
• Molecular Weight: 195.17206
• Mol File: 52095-18-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 363.5±30.0 °C(Predicted)
• Appearance: /
• Density: 1.333±0.06 g/cm3(Predicted)
• PKA: 2.28±0.25(Predicted)
• CAS DataBase Reference: 3,5-diMethyl-2-nitrobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-diMethyl-2-nitrobenzoic acid(52095-18-8)
• EPA Substance Registry System: 3,5-diMethyl-2-nitrobenzoic acid(52095-18-8)

Safety Data

• Hazardous Substances Data: 52095-18-8(Hazardous Substances Data)

Usage

General Description

3,5-diMethyl-2-nitrobenzoic acid is a chemical compound with the formula C9H9NO4. It is a derivative of benzoic acid and contains a nitro group as well as two methyl groups. 3,5-diMethyl-2-nitrobenzoic acid is commonly used as a raw material for the synthesis of pharmaceuticals and dyes. It has also been utilized in the study of enzyme kinetics and in the field of organic chemistry as a reagent. The presence of the nitro group makes 3,5-diMethyl-2-nitrobenzoic acid an important intermediate in the production of various other organic compounds.

Upstream product

• 499-06-9 3,5-dimethylbenzoic acid 
• 7697-37-2 nitric acid 
• 603-71-4 nitromesitylene 
• 108-67-8 1,3,5-trimethyl-benzene 
• 14438-32-5 3,5-dimethylanthranilic acid 

Downstream Products

• 14438-32-5 3,5-dimethylanthranilic acid 
• 7697-33-8 2-bromo-3,5-dimethyl-benzoic acid 
• 686753-06-0 N-(2,2-dimethylpropyl)-3,5-dimethyl-2-nitrobenzamide 
• 686753-07-1 N-(2,2-dimethylpropyl)-3,5,N-trimethyl-2-nitrobenzamide 
• 349453-68-5 2-amino-N-(2,2-dimethylpropyl)-3,5,N-trimethylbenzamide 
• 95-68-1 2,4-Xylidine 
• 198220-36-9 3,5-dimethyl-2-iodobenzoic acid 
• 873388-89-7 (2-amino-3,5-dimethylphenyl)methanol 
• 1228047-60-6 1-(bromomethyl)-3,5-dimethyl-2-nitrobenzene 
• 54893-32-2 2-(3,5-dimethyl-2-nitrophenyl)acetonitrile 

Relevant articles and documents

Divergent Syntheses of Indoles and Quinolines Involving N1-C2-C3 Bond Formation through Two Distinct Pd Catalyses

Pd-catalyzed annulative couplings of 2-alkenylanilines with aldehydes using alcohols as both the solvent and hydrogen source have been developed. These domino processes allow divergent syntheses of two significant N-heterocycles, indoles and quinolines, from the same substrate by tuning reaction parameters, which seems to invoke two distinct mechanisms. The nature of the ligand and alcoholic solvent had a profound influence on the selectivity and efficiency of these protocols. Particularly noteworthy is that indole formation was achieved by overcoming two significant challenges, regioselective hydropalladation of alkenes and subsequent reactions between the resulting Csp3-Pd species and less reactive imines.

Method for synthetizing 2-amino-1, 3, 5-benzenetricarboxylic acid and application thereof for preparation of NH2-MOF-808

The invention belongs to the field of preparation and application of organic compounds and metal-organic framework compounds, and discloses a method for synthetizing 2-amino-1, 3, 5-benzenetricarboxylic acid and an application thereof for preparation of a

Discovery, Modeling, and Human Pharmacokinetics of N-(2-Acetyl-4,6-dimethylphenyl)-3-(3,4-dimethylisoxazol-5-ylsulfamoyl) -thiophene-2-carboxamide (TBC3711), a Second Generation, ETA Selective, and Orally Bioavailable Endothelin Antagonist

Sitaxsentan (1) (Wu et al. J. Med. Chem. 1997, 40, 1690) is our first endothelin antagonist being evaluated in clinical trials. It has demonstrated biological effects in an acute hemodynamic study in CHF (Givertz et al. Circulation 2000, 101, 2922), an op