521-54-0Relevant articles and documents
NEOLIGNANS FROM NECTANDRA PUBERULA
Moro, Jose C.,Fernandes, Joao B.,Vieira, Paulo C.,Yoshida, Massayoshi,Gottlieb, Otto R.,Gottlieb, Hugo E.
, p. 269 - 272 (1987)
The trunk wood of Nectandra puberula was found to contain 1,6-geranylgeranodioic acid besides five neoligands, the known veraguensin and the novel 7-hydroxy- and 7-oxo-3,4,3',4'-tetraoxy-8,8'-neolignans, all with the (8S,8'R-)-absolute configuration. Key Word Index--Nectandra puberula; Lauraceae; geranylgeranodioic acid; neolignans; diaryldimethyl-n-butanones.
Efficient Total Synthesis of (±)-Isoguaiacin and (±)-Isogalbulin
Pilkington, Lisa I.,Song, Soo Min,Fedrizzi, Bruno,Barker, David
, p. 1449 - 1452 (2017/07/22)
1-Arylnaphthalene lignans such as (-)-isoguaiacin and (-)-isogalbulin have been reported to exhibit notable biological properties. While (-)-isoguaiacin has not been previously synthesized, syntheses of (-)-isogalbulin are generally long and produce a mixture of stereoisomers. We herein present the efficient total synthesis of (±)-isoguaiacin and (±)-isogalbulin in seven and eight steps with an overall yield of 46% and 36%, respectively. The reported approach harnesses a hydrogenolysis reaction in acidic conditions, to convert a furan into an arylnaphthalen structure.
Collective synthesis of several 2,7′-cyclolignans and their correlation by chemical transformations
Peng, Yu,Luo, Zhen-Biao,Zhang, Jian-Jian,Luo, Long,Wang, Ya-Wen
, p. 7574 - 7586 (2013/11/06)
Collective synthesis of anti-malarial 2,7′-cyclolignans has been stereoselectively achieved employing (±)-cyclogalgravin (2) as a linchpin through a series of functional group conversions, including redox reactions. Interestingly, 2 can be correlated with