521-55-1Relevant articles and documents
Total synthesis of (+)-galbulin and unnatural lignans
Clausen, Florian,Studer, Armido
supporting information, p. 6780 - 6783 (2020/09/15)
The total synthesis of (+)-galbulin was achieved in 15% yield and 99% ee over eight steps from commercially available 4-veratraldehyde. The key steps include Meyer's asymmetric tandem addition to a chiral 2-oxazoline-substituted naphthalene, a Pd-catalyzed stereospecific decarboxylative γ-arylation, and a formal anti-Markovnikov hydromethylation. In addition, five unnatural lignans were synthesized using the same synthetic strategy.
A practical total synthesis of (+)-isogalbulin and (+)-galbulin
Li, Xiaoyu,Jiao, Xiaozhen,Liu, Xiaoyu,Tian, Chengsen,Dong, Liang,Yao, Yangyang,Xie, Ping
, p. 6324 - 6327 (2015/02/19)
A practical total synthesis of the natural products (+)-isogalbulin and (+)-galbulin has been achieved in 10 steps from readily available 3-(3,4-dimethoxyphenyl)propanoic acid. The total yields were 12.3% and 12.9%, respectively. The key steps involved Ev
Enantioselective total synthesis of (+)-galbulin via organocatalytic domino Michael-Michael-aldol condensation
Hong, Bor-Cherng,Hsu, Che-Sheng,Lee, Gene-Hsiang
supporting information; experimental part, p. 2385 - 2387 (2012/03/27)
A concise and practical enantioselective synthesis of (+)-galbulin has been achieved using organocatalytic domino Michael-Michael-aldol condensation and organocatalytic kinetic resolution as the key steps. The Royal Society of Chemistry 2012.
