52107-84-3

Basic information

• Product Name: 3'-IODO-4'-METHYLACETOPHENONE
• Synonyms: 3'-IODO-4'-METHYLACETOPHENONE;ETHANONE, 1-(3-IODO-4-METHYLPHENYL)-;1-(3-Iodo-4-methylphenyl)ethanone
• CAS NO: 52107-84-3
• Molecular Formula: C₉H₉IO
• Molecular Weight: 260.07
• Product Categories: Adehydes, Acetals & Ketones;Iodine Compounds
• Mol File: 52107-84-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 306.516 °C at 760 mmHg
• Flash Point: 139.176 °C
• Appearance: /
• Density: 1.632 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3'-IODO-4'-METHYLACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-IODO-4'-METHYLACETOPHENONE(52107-84-3)
• EPA Substance Registry System: 3'-IODO-4'-METHYLACETOPHENONE(52107-84-3)

Safety Data

• Hazardous Substances Data: 52107-84-3(Hazardous Substances Data)

Usage

Description

3'-IODO-4'-METHYLACETOPHENONE, with the molecular formula C9H9IO, is a substituted acetophenone characterized by the presence of an iodine atom at the 3' position and a methyl group at the 4' position. This yellowish solid at room temperature is known for its mild aromatic odor and is widely recognized for its applications in organic synthesis and potential therapeutic properties.

Uses

Used in Organic Synthesis:
3'-IODO-4'-METHYLACETOPHENONE is used as a building block for the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. Its unique structure allows it to be a versatile component in the creation of a broad range of chemical products.
Used in Medicinal and Biological Applications:
3'-IODO-4'-METHYLACETOPHENONE is utilized for its pharmacological activities, making it a candidate for potential therapeutic properties. It is being studied for its possible applications in medicine and biology, which may lead to new treatments and advancements in these fields.

Upstream product

• 122-00-9 para-methylacetophenone 
• 2089-33-0 4-methylacethophenone oxime 
• 42872-79-7 3-iodo-4-methylbenzonitrile 
• 82998-57-0 3-iodo-4-toluic acid 
• 60710-80-7 5-cyano-2-methylaniline 

Relevant articles and documents

N-Iodosuccinimide (NIS) in Direct Aromatic Iodination

N-Iodosuccinimide (NIS) in pure trifluoroacetic acid (TFA) offers a time-efficient and general method for the iodination of a wide range of mono- and disubstituted benzenes at room temperature, as demonstrated in this paper. The starting materials were generally converted into mono-iodinated products in less than 16 hours at room temperature, without byproducts. A few deactivated substrates needed addition of sulfuric acid to increase the reaction rate. Another exception was methoxybenzenes that preferentially were iodinated by NIS in acetonitrile with only catalytic amounts of TFA.

Reactions of Aryl Ketones and Coumarins with Iodine(III) Tris(trifluoroacetate)

The reaction of acetophenones with iodine(III) tris(trifluoroacetate) yields 3'- and/or 2-iodo derivatives, depending upon the substituent on the aromatic ring and the reaction conditions.The reaction was examinedby changing the molar ratio of acetophenone versus the reagent, reaction temperature, and solvent.In similar reactions flavanones and coumarins gave iodo derivatives in which iodine is incorporated at various positions orientated by the oxygen functions. 1,2-Diphenylethanone yields 2-hydroxy-2-(2-iodophenyl)-1-phenylethanone and 1-(2-iodophenyl)-2-phenylethanedione.The reactions of other aromatic ketones such as 9-xanthenone, 9-fluorenone, and anthrone also give iodo derivatives in moderate to good yields.The mechanisms for the iodination at the α-carbon to the carbonyl group have been discussed.