521098-18-0

Basic information

• Product Name: 2-(3,5-di-tert-butyl-4-hydroxy-phenyl)-N-{3-[(thiophene-2-carboximidoyl)-amino]-benzyl}-acetamide
• CAS NO: 521098-18-0
• Molecular Weight: 477.671
• Mol File: 521098-18-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(3,5-di-tert-butyl-4-hydroxy-phenyl)-N-{3-[(thiophene-2-carboximidoyl)-amino]-benzyl}-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,5-di-tert-butyl-4-hydroxy-phenyl)-N-{3-[(thiophene-2-carboximidoyl)-amino]-benzyl}-acetamide(521098-18-0)
• EPA Substance Registry System: 2-(3,5-di-tert-butyl-4-hydroxy-phenyl)-N-{3-[(thiophene-2-carboximidoyl)-amino]-benzyl}-acetamide(521098-18-0)

Safety Data

• Hazardous Substances Data: 521098-18-0(Hazardous Substances Data)

Upstream product

• 147291-66-5 3-tert-butoxycarbonylaminomethylaniline 
• 147291-65-4 N-(3-nitrophenylmethyl)carbamic acid t-butyl ester 
• 1611-03-6 3,5-di-tert-butyl-4-hydroxyphenyl acetic acid 

Relevant articles and documents

Novel inhibitors of neuronal nitric oxide synthase with potent antioxidant properties.

A series of hybrid compounds possessing an nNOS pharmacophore linked to an antioxidant fragment has been synthesized. Among them, compound 8d, a propofol derivative, displayed the greatest dual potencies against nNOS (IC(50)=0.12 microM) and lipid peroxidation (IC(50)=0.4 microM) accompanied with e/nNOS selectivity (67.5). This shows that nNOS was able to accommodate very bulky groups such as di-tert-butyl or di-iso-propyl phenol in its active site.