521273-76-7

Basic information

• Product Name: Piperidin-4-ylmethyl-pyrimidin-2-yl-amine
• Synonyms: PIPERIDIN-4-YLMETHYL-PYRIMIDIN-2-YL-AMINE;N-(4-piperidinylmethyl)-2-Pyrimidinamine
• CAS NO: 521273-76-7
• Molecular Formula: C₁₀H₁₆N₄
• Molecular Weight: 192.27
• Mol File: 521273-76-7.mol
• Article Data: 2

Chemical Properties

• Melting Point: 73-75 °C
• Boiling Point: 349.62 °C at 760 mmHg
• Flash Point: 165.244 °C
• Appearance: /
• Density: 1.106 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.563
• PKA: 10.48±0.10(Predicted)
• CAS DataBase Reference: Piperidin-4-ylmethyl-pyrimidin-2-yl-amine(CAS DataBase Reference)
• NIST Chemistry Reference: Piperidin-4-ylmethyl-pyrimidin-2-yl-amine(521273-76-7)
• EPA Substance Registry System: Piperidin-4-ylmethyl-pyrimidin-2-yl-amine(521273-76-7)

Safety Data

• Hazardous Substances Data: 521273-76-7(Hazardous Substances Data)

Usage

General Description

Piperidin-4-ylmethyl-pyrimidin-2-yl-amine is a chemical compound that belongs to the class of organic compounds known as phenylpiperidines, which are aromatic compounds containing a phenyl group and a piperidine ring. This particular chemical is characterized by the presence of a pyrimidin-2-yl-amine group attached to the piperidine ring via a methylene bridge. The exact properties of this compound, such as its solubility, melting point, and toxicological profile, are not well-documented, likely because it is a relatively obscure substance. However, its structure suggests that it could be investigated for potential use in pharmaceutical or synthetic chemistry applications.

InChI:InChI=1/C10H16N4/c1-4-12-10(13-5-1)14-8-9-2-6-11-7-3-9/h1,4-5,9,11H,2-3,6-8H2,(H,12,13,14)

Upstream product

• 455265-24-4 benzyl 4-[(2-pyrimidinylamino)methyl]-1-piperidinecarboxylate 
• 157023-34-2 4-aminomethyl-piperidine-1-carboxylic acid benzyl ester 
• 1722-12-9 2-chloropyrimidine 
• 455267-58-0 5-fluoro-N-(piperidin-4-ylmethyl)pyrimidin-2-amine 
• 455265-89-1 4-[(5-fluoro-pyrimidin-2-ylamino)-methyl]-piperidine-1-carboxylic acid benzyl ester 
• 7144-05-0 4-Aminomethylpiperidine 

Downstream Products

• 1374602-21-7 C₂₈H₃₉ClN₆O₂ 

Relevant articles and documents

Identification and characterization of 4-methylbenzyl 4-[(pyrimidin-2- ylamino)methyl]piperidine-1-carboxylate, an orally bioavailable, brain penetrant NR2B selective N-methyl-D-aspartate receptor antagonist

The discovery of a novel series of NR2B subtype selective N-methyl-D-aspartate (NMDA) antagonists is reported. Initial optimization of a high-throughput screening lead afforded an aminopyridine derivative 13 with significant NR2B antagonist potency but limited selectivity over hERG-channel and other off-target activities. Further structure-activity studies on the aminoheterocycle moiety and optimization of the carbamate led to the highly potent 2-aminopyrimidine derivative 20j with a significantly improved off-target activity profile and oral bioavailability in multiple species coupled with good brain penetration. Compound 20j demonstrated efficacy in in vivo rodent models of antinociception, allodynia, and Parkinson's disease.