521275-21-8

Basic information

• Product Name: carbonic acid 1-{N-benzyl-N'-[(2,6-dimethyl-phenoxy)-acetyl]-hydrazinocarbonyl}-2-tert-butoxycarbonylamino-3-phenyl-propyl ester isobutyl ester
• CAS NO: 521275-21-8
• Molecular Weight: 661.795
• Mol File: 521275-21-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: carbonic acid 1-{N-benzyl-N'-[(2,6-dimethyl-phenoxy)-acetyl]-hydrazinocarbonyl}-2-tert-butoxycarbonylamino-3-phenyl-propyl ester isobutyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: carbonic acid 1-{N-benzyl-N'-[(2,6-dimethyl-phenoxy)-acetyl]-hydrazinocarbonyl}-2-tert-butoxycarbonylamino-3-phenyl-propyl ester isobutyl ester(521275-21-8)
• EPA Substance Registry System: carbonic acid 1-{N-benzyl-N'-[(2,6-dimethyl-phenoxy)-acetyl]-hydrazinocarbonyl}-2-tert-butoxycarbonylamino-3-phenyl-propyl ester isobutyl ester(521275-21-8)

Safety Data

• Hazardous Substances Data: 521275-21-8(Hazardous Substances Data)

Upstream product

• 555-96-4 Benzylhydrazine 
• 13335-71-2 2-(2,6-dimethylphenoxy)acetic acid 
• 62023-65-8 (2S,3S)-3-tert-butoxycarbonylamino-2-hydroxy-4-phenylbutanoic acid 
• 521275-19-4 (2,6-dimethyl-phenoxy)-acetic acid N'-benzyl-hydrazide 
• 543-27-1 isobutyl chloroformate 

Downstream Products

• 521275-30-9 carbonic acid 1-{N-benzyl-N'-[(2,6-dimethyl-phenoxy)-acetyl]-hydrazinocarbonyl}-2-(2-tert-butoxycarbonylamino-3-methylsulfanyl-propionylamino)-3-phenyl-propyl ester isobutyl ester 

Relevant articles and documents

Design and synthesis of pseudo-symmetric HIV protease inhibitors containing a novel hydroxymethylcarbonyl (HMC)-hydrazide isostere.

Pseudo-symmetric HIV-1 protease inhibitors containing a novel HMC-hydrazide isostere as the transition-state mimic were designed and synthesized. Most of the synthetic compounds with varied structures at the P and P' sites around this core unit showed potent inhibitory activity against HIV-1 protease with nanomolar K(i) values.