521290-74-4Relevant articles and documents
Discovery and SAR of hydrazide antagonists of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor type 1 (PAC1-R)
Beebe, Xenia,Darczak, Daria,Davis-Taber, Rachel A.,Uchic, Marie E.,Scott, Victoria E.,Jarvis, Michael F.,Stewart, Andrew O.
, p. 2162 - 2166 (2008/09/20)
Potent small molecule antagonists for the PAC1-R have been discovered. Previously known antagonists for the PAC1-R were slightly truncated peptide ligands. The hydrazides reported here are the first small molecule antagonists ever reported for this class B GPCR.