521302-88-5

Basic information

• Product Name: tert-butyl (2R,3R)-2-(benzyloxycarbonyl)amino-3-iodobutanoate
• Synonyms: tert-butyl (2R,3R)-2-(benzyloxycarbonyl)amino-3-iodobutanoate
• CAS NO: 521302-88-5
• Molecular Weight: 419.259
• Mol File: 521302-88-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl (2R,3R)-2-(benzyloxycarbonyl)amino-3-iodobutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (2R,3R)-2-(benzyloxycarbonyl)amino-3-iodobutanoate(521302-88-5)
• EPA Substance Registry System: tert-butyl (2R,3R)-2-(benzyloxycarbonyl)amino-3-iodobutanoate(521302-88-5)

Safety Data

• Hazardous Substances Data: 521302-88-5(Hazardous Substances Data)

Upstream product

• 72289-51-1 tert-butyl (2S,3R)-2-(benzyloxycarbonyl)amino-3-hydroxybutanoate 
• 19728-63-3 N-benzyloxycarbonyl-L-treonine 
• 521302-84-1 tert-butyl (2S,3R)-2-(benzyloxycarbonyl)amino-3-iodobutanoate 

Relevant articles and documents

Palladium(O) catalysed and copper(I) promoted reactions of the secondary zinc reagent derived from L-threonine

The preparation of C-3 epimeric secondary zinc reagents from diastereoisomeric iodide using DMF as solvent was discussed and analyzed by NMR methods. Palladium catalysed cross couplings and copper promoted allylations produced protected β-methyl substituted amino acids. It was concluded that the threonine derived zinc reagents were of limited values, but further optimization of copper-promoted reactions make this approach to synthesis of β-methyl substituted α-amino acids more useful.