52163-89-0 Usage
Description
3-(2-Fluorophenyl)propionyl chloride 98, with the molecular formula C9H8ClF and a molecular weight of 174.61 g/mol, is a colorless to pale yellow liquid characterized by a strong, pungent odor. This chemical compound serves as a crucial intermediate in the synthesis of pharmaceuticals and agrochemicals, and is also a valuable building block for the production of various organic compounds. Furthermore, it finds application in the manufacture of dyes and other specialty chemicals.
Uses
Used in Pharmaceutical Industry:
3-(2-Fluorophenyl)propionyl chloride 98 is used as a key intermediate for the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 3-(2-Fluorophenyl)propionyl chloride 98 is utilized as a vital component in the production of agrochemicals, contributing to the development of effective pest control solutions and other agricultural products.
Used in Organic Compounds Production:
3-(2-Fluorophenyl)propionyl chloride 98 is used as a valuable building block for the production of a wide range of organic compounds, enabling the creation of diverse chemical entities for various applications.
Used in Dyes and Specialty Chemicals Manufacturing:
This chemical compound is also employed in the manufacture of dyes and other specialty chemicals, where its specific properties contribute to the development of high-quality products with unique characteristics.
Safety Precautions:
Due to its corrosive nature, 3-(2-Fluorophenyl)propionyl chloride 98 may cause skin and eye irritation upon contact. Therefore, it is essential to handle this chemical with care and take appropriate safety measures to minimize potential hazards.
Check Digit Verification of cas no
The CAS Registry Mumber 52163-89-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,1,6 and 3 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 52163-89:
(7*5)+(6*2)+(5*1)+(4*6)+(3*3)+(2*8)+(1*9)=110
110 % 10 = 0
So 52163-89-0 is a valid CAS Registry Number.
52163-89-0Relevant articles and documents
Cyclohexyl-Fused, Spirobiindane-Derived, Phosphine-Catalyzed Synthesis of Tricyclic ?3-Lactams and Kinetic Resolution of ?3-Substituted Allenoates
Wu, Mingyue,Han, Zhaobin,Li, Kaizhi,Wu, Ji'En,Ding, Kuiling,Lu, Yixin
, p. 16362 - 16373 (2019/10/16)
A C2-symmetric chiral phosphine catalyst, NUSIOC-Phos, which can be easily derived from cyclohexyl-fused spirobiindane, was introduced. A highly enantioselective domino process involving pyrrolidine-2,3-diones and γ-substituted allenoates catalyzed by NUSIOC-Phos has been disclosed. Diastereospecific tricyclic γ-lactams containing five contiguous stereogenic centers were obtained in high yields and with nearly perfect enantioselectivities. A kinetic resolution process of racemic γ-substituted allenoates was developed for the generation of optically enriched chiral allenoates.
Carboxy Group as a Remote and Selective Chelating Group for C?H Activation of Arenes
Li, Shangda,Wang, Hang,Weng, Yunxiang,Li, Gang
supporting information, p. 18502 - 18507 (2019/11/14)
The first example of carboxy group assisted, remote-selective C(sp2)?H activation with a PdII catalyst has been developed and proceeds through a possible κ2 coordination of the carboxy group, thus suppressing the ortho-C?H activation through κ1 coordination. Besides meta-C?H olefination, direct meta-arylation of hydrocinnamic acid derivatives with low-cost aryl iodides has been achieved for the first time. These findings may motivate the exploration of novel reactivities of the carboxy assisted C?H activation reactions with intriguing selectivities.
Cross-coupling of remote meta -c-h bonds directed by a u-shaped template
Wan, Li,Dastbaravardeh, Navid,Li, Gang,Yu, Jin-Quan
supporting information, p. 18056 - 18059 (2014/01/06)
meta-C-H arylation and methylation of 3-phenylpropanoic acid and phenolic derivatives were developed using an easily removable nitrile template. The combination of a weakly coordinating U-shaped template and mono-protected amino acid ligand was crucial fo