52173-35-0

Basic information

• Product Name: N-(3-FLUORO-PHENYL)-3-OXO-BUTYRAMIDE
• Synonyms: N-(3-FLUOROPHENYL)-3-OXOBUTANAMIDE;N-(3-FLUORO-PHENYL)-3-OXO-BUTYRAMIDE
• CAS NO: 52173-35-0
• Molecular Formula: C₁₀H₁₀FNO₂
• Molecular Weight: 195.19
• Mol File: 52173-35-0.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(3-FLUORO-PHENYL)-3-OXO-BUTYRAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-FLUORO-PHENYL)-3-OXO-BUTYRAMIDE(52173-35-0)
• EPA Substance Registry System: N-(3-FLUORO-PHENYL)-3-OXO-BUTYRAMIDE(52173-35-0)

Safety Data

• Hazardous Substances Data: 52173-35-0(Hazardous Substances Data)

Usage

General Description

N-(3-fluoro-phenyl)-3-oxo-butyramide is a chemical compound with the molecular formula C10H10FNO2. It belongs to the class of organic compounds known as benzamides and derivatives and is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. N-(3-FLUORO-PHENYL)-3-OXO-BUTYRAMIDE has a molecular weight of 195.188 g/mol and is characterized by its yellow to brown color. It is important to handle this chemical with caution as it may pose hazards to human health and the environment if not used and disposed of properly.

Upstream product

• 674-82-8 4-methyleneoxetan-2-one 
• 372-19-0 meta-fluoroaniline 
• 141-97-9 ethyl acetoacetate 
• 105-45-3 acetoacetic acid methyl ester 
• 541-50-4 2-acetoacetic acid 
• 5394-63-8 2,2,6-trimethyl-4H-1,3-dioxin-4-one 

Downstream Products

• 957375-99-4 N²-(3-fluorophenyl)-5-amino-3-methyl-2,4-thiophenecarboxamide 
• 271241-24-8 7-fluoro-2-hydroxy-4-methylquinoline 
• 1155195-62-2 4-bromo-N-(3-fluorophenyl)-3-oxobutanamide 
• 1282423-36-2 C₂₇H₂₁ClFN₅OS 
• 1282423-19-1 C₂₇H₂₁ClFN₅O₂ 
• 1607002-99-2 cetyl-1-(3-fluorophenyl)-1H-chromeno[4,3-b]pyridine-2,5-dione3- 
• 271241-24-8 7-fluoro-4-methylquinolin-2(1H)-one 

Relevant articles and documents

Ru-NHC-Catalyzed Asymmetric Hydrogenation of 2-Quinolones to Chiral 3,4-Dihydro-2-Quinolones

Direct enantioselective hydrogenation of unsaturated compounds to generate chiral three-dimensional motifs is one of the most straightforward and important approaches in synthetic chemistry. We realized the Ru(II)-NHC-catalyzed asymmetric hydrogenation of 2-quinolones under mild reaction conditions. Alkyl-, aryl- and halogen-substituted optically active dihydro-2-quinolones were obtained in high yields with moderate to excellent enantioselectivities. The reaction provides an efficient and atom-economic pathway to construct simple chiral 3,4-dihydro-2-quinolones. The desired products could be further reduced to tetrahydroquinolines and octahydroquinolones.

One-pot synthesis of 3-hydroxyquinolin-2(1 H)-ones from N-phenylacetoacetamide via PhI(OCOCF3)2-mediated α-hydroxylation and H2SO4-promoted intramolecular cyclization

A clean, one-pot synthesis of the biologically important 3-hydroxyquinolin-2(1H)-one compounds has been realized from the readily available N-phenylacetoacetamide derivatives through a PhI(OCOCF 3)2-mediated α-hydroxylation and a H 2SO4-promoted intramolecular condensation. The hydroxyl group in the generated α-hydroxylated intermediate can be well tolerated in the second H2SO4-promoted cyclization step.

THERAPEUTIC AGENTS I

Compounds of formula(I), processes for preparing such compounds, their use in the treatment of obesity, psychiatric disorders, cognitive disorders, memory disorders, schizophrenia, epilepsy, and related conditions, and neurological disorders such as dementia, multiple sclerosis, Parkinson's disease, Huntington's chorea and Alzheimer's disease and pain related disorders, and pharmaceutical compositions containing them.