52178-61-7

Basic information

• Product Name: 2-hydroxy-3-(4-hydroxyphenyl)acrylic acid
• Synonyms: 2-hydroxy-3-(4-hydroxyphenyl)acrylic acid
• CAS NO: 52178-61-7
• Molecular Weight: 180.16
• Mol File: 52178-61-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-hydroxy-3-(4-hydroxyphenyl)acrylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-3-(4-hydroxyphenyl)acrylic acid(52178-61-7)
• EPA Substance Registry System: 2-hydroxy-3-(4-hydroxyphenyl)acrylic acid(52178-61-7)

Safety Data

• Hazardous Substances Data: 52178-61-7(Hazardous Substances Data)

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 52507-17-2 (Z)-4-((2-methyl-5-oxooxazol-4(5H)-ylidene)methyl)phenyl acetate 
• 556-02-5 ?Tyr 
• 64896-33-9 (Z)-2-acetamido-3-(p-hydroxyphenyl)-2-propenic acid 

Downstream Products

• 214534-53-9 (Z)-2-hydroxy-3-(4-hydroxyphenyl)prop-2-enoic acid methyl ester 
• 6482-98-0 2-hydroxy-3-(4-hydroxyphenyl)propanoic acid 

Relevant articles and documents

Synthesis and biological activities of a series of 4,5-diaryl-3-hydroxy-2(5H)-furanones

A series of thirteen 4,5-diaryl-3-hydroxy-2(5H)-furanones were synthesized. They were evaluated for their antioxidant potencies and inhibitory properties of 5-lipoxygenase, cyclooxygenases, HIV-1 integrase and PC3 cell proliferation. New hits were discove

Mechanistic and stereochemical study of phenylpyruvate tautomerase

A variety of substrates and potential enol/enolate mimics for the product/transition state of the enzyme phenylpyruvate tautomerase (E.C. 5.3.2.1) have been prepared and studied. Their stereostructures have been secured by a combination of NMR spectroscopy based on vicinal H-F and H-C coupling constants and X-ray crystallography. On the basis of the inhibition by stereoisomeric substituted cinnamates, it has been concluded that the enzyme produces the thermodynamically less stable (E) enol via a syn tautomerization transition state. Free energy profiles for the reaction suggest that vinyl fluorides act as product analogues. Because amide and dicarboxylate enolate mimics are relatively poor inhibitors of the enzyme, it is believed that an enolate is not involved in the tautomerization process.

Conversion of Phenolic α-Amino Acids into α-Keto Acids

A one-pot conversion of tyrosine (1a) and 3,4-dihydroxyphenylalanine (DOPA) (1b) into 3-(4-hydroxyphenyl)pyruvic acid (2a) and 3-(3,4-dihydroxyphenyl)pyruvic acid (2b), respectively, via 2-trifluoromethyl-3-oxazolin-5-ones 5 is described.