5219-08-9

Basic information

• Product Name: 2-(4-methoxyphenyl)acetoacetic acid ethyl ester
• Synonyms: 2-(4-methoxyphenyl)acetoacetic acid ethyl ester
• CAS NO: 5219-08-9
• Molecular Weight: 236.268
• Mol File: 5219-08-9.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 2-(4-methoxyphenyl)acetoacetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxyphenyl)acetoacetic acid ethyl ester(5219-08-9)
• EPA Substance Registry System: 2-(4-methoxyphenyl)acetoacetic acid ethyl ester(5219-08-9)

Safety Data

• Hazardous Substances Data: 5219-08-9(Hazardous Substances Data)

Upstream product

• 18649-43-9 4-methoxyphenyllead(IV) triacetate 
• 141-97-9 ethyl acetoacetate 
• 64-17-5 ethanol 
• 63895-78-3 2-(4-methoxyphenyl)-3-oxobutanenitrile 
• 623-73-4 diazoacetic acid ethyl ester 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 13298-59-4 2-diazo-1-(4-methoxyphenyl)butane-1,3-dione 
• 104-47-2 p-methoxybenzylnitrile 
• 696-62-8 para-iodoanisole 

Downstream Products

• 5219-16-9 7-hydroxy-3-(4-methoxyphenyl)-4-methyl-2H-chromen-2-one 
• 1068515-17-2 4-(4-methoxyphenyl)-3-methyl-1-(pyridin-2-yl)-1H-pyrazol-5-ol 
• 1160169-27-6 (Z)-ethyl 3-amino-2-(4-methoxyphenyl)but-2-enoate 
• 1092495-62-9 8-cyclopropylmethoxy-5-fluoro-3-(4-methoxyphenyl)-2-methyl-1H-quinolin-4-one 

Relevant articles and documents

Synthetic Scope of Br?nsted Acid-Catalyzed Reactions of Carbonyl Compounds and Ethyl Diazoacetate

The comprehensive study of the reactions of carbonyl compounds and ethyl diazoacetate in the presence of a Br?nsted acid catalyst is described. In result, a broad range of 3-oxo-esters were synthesized from a variety of ketones and aliphatic aldehydes by 1,2-aryl/alkyl/hydride shift. Aryl-methyl ketones produced only aryl-migrated products, whereas other ketones yielded a mixture of products. For diaryl ketones, the identity of two inseparable migrated products was confirmed by two-dimensional NMR spectroscopy.

Synthesis and biological evaluation of substituted pyrazoles as blockers of divalent metal transporter 1 (DMT1)

Three distinct series of substituted pyrazole blockers of divalent metal transporter 1 (DMT1) were elaborated from the high-throughput screening pyrazolone hit 1. Preliminary hit-to-lead efforts revealed a preference for electron-withdrawing substituents in the 4-amido-5-hydroxypyrazole series 6a-l. In turn, this preference was more pronounced in a series of 4-aryl-5- hydroxypyrazoles 8a-j. The representative analogs 6f and 12f were found to be efficacious in a rodent model of acute iron hyperabsorption. These three series represent promising starting points for lead optimization efforts aimed at the discovery of DMT1 blockers as iron overload therapeutics.

QUINOLONE COMPOUND AND PHARMACEUTICAL COMPOSITION

The present invention provides a quinolone compound represented by General Formula (1) or a salt thereof, wherein R1 represents a hydrogen atom, etc.; R2 represents a hydrogen atom, etc.; R3 represents a phenyl group optio