522-18-9

Basic information

• Product Name: chlorbenzoxamine
• Synonyms: chlorbenzoxamine;1-[2-[(2-Chlorophenyl)phenylmethoxy]ethyl]-4-[(2-methylphenyl)methyl]piperazine;Chlorbenzoxyethamine;Chlorobenzoxamine
• CAS NO: 522-18-9
• Molecular Formula: C₂₇H₃₁ClN₂O
• Molecular Weight: 435
• EINECS: 208-323-0
• Mol File: 522-18-9.mol
• Article Data: 0

Chemical Properties

• Boiling Point: bp0.01 234-236°; bp0.005 235°
• Flash Point: 276.9°C
• Appearance: /
• Density: 1.144g/cm³
• Vapor Pressure: 1.72E-11mmHg at 25°C
• Refractive Index: 1.594
• CAS DataBase Reference: chlorbenzoxamine(CAS DataBase Reference)
• NIST Chemistry Reference: chlorbenzoxamine(522-18-9)
• EPA Substance Registry System: chlorbenzoxamine(522-18-9)

Safety Data

• Hazardous Substances Data: 522-18-9(Hazardous Substances Data)

Usage

Originator

Chlorbenzoxamine,Shanghai

Manufacturing Process

A mixture of 0.1 mol of 1-m-methylbenzyl-4-(2-hydroxyethyl)-piperazine and 0.1 mol of o-chlorobenzhydrile chloride was heated at 160°C for 3 hours. After cooling the product obtained was dissolved in benzene. The solution was washed with 20% aqueous solution of sodium carbonate and then with water. Chlorbenzoxamine was distilled in vacuo, B.P. 240°C/0.1 mm Hg. Yield 50%.

InChI:InChI=1/C27H31ClN2O/c1-22-9-5-6-12-24(22)21-30-17-15-29(16-18-30)19-20-31-27(23-10-3-2-4-11-23)25-13-7-8-14-26(25)28/h2-14,27H,15-21H2,1H3

Upstream product

• 89-92-9 2-methylbenzyl bromide 
• 5321-47-1 1-(2-methylbenzyl)piperazine