522-96-3 Usage
Description
A berberine type alkaloid, first isolated from Sinorneniurn acuturn Rehd. and Wits and also present in both the (-)- and (±)-forms in Fagara officinalis L., crystallizes from EtOH in colourless prisms. It has [α]D - 312° (CHC13 ) and yields a sparingly soluble hydrochloride, m.p. 272°C (dec.) and a platinichloride, m.p. 245-7°C. On oxidation with iodine in EtOH it forms an iodide as orangeyellow needles, m.p. 300°C (dec.) which, on treatment with silver chloride in H2 0 gives dehydrosinactine chloride, identical with epiberberinium chloride.
References
Goto, Sudzuki., Bull. Chern. Soc., Japan, 4, 220 (1929) Goto, Kitasato., J. Chern. Soc., 1234 (1930)
Check Digit Verification of cas no
The CAS Registry Mumber 522-96-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,2 and 2 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 522-96:
(5*5)+(4*2)+(3*2)+(2*9)+(1*6)=63
63 % 10 = 3
So 522-96-3 is a valid CAS Registry Number.
522-96-3Relevant articles and documents
Convenient synthesis of 2,3,9,10-tetraoxygenated protoberberine alkaloids and their 13-methyl alkaloids
Hanaoka, Miyoji,Hirasawa, Taeko,Cho, Won Jea,Yasuda, Shingo
, p. 399 - 404 (2007/10/03)
New and convenient synthesis of 2,3,9,10-tetraoxygenated protoberberine alkaloids and their 13-methyl alkaloids through the same intermediates was developed. Acylation of the brominated benzylphenethylamine (13) with α- chloro-α-(methylthio)acetyl chloride, followed by cyclization with stannic chloride, furnished the key intermediates 4-methylthio-3- phenethylisoquinolin-3-ones (14), which were methylated to provide their methyl derivatives (17). Both isoquinolin-3-ones (14, 17) were easily transformed into protoberberine alkaloids (16) and their 13-methyl alkaloids (21) in good yield.
