52210-93-2

Basic information

• Product Name: 2-(4-Allyloxy-phenoxymethyl)-oxirane
• Synonyms: Oxirane, 2-[[4-(2-propen-1-yloxy)phenoxy]methyl]-
• CAS NO: 52210-93-2
• Molecular Formula: C₁₂H₁₄O₃
• Molecular Weight: 206.24
• Mol File: 52210-93-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 325.7°Cat760mmHg
• Flash Point: 109.1°C
• Appearance: /
• Density: 1.109g/cm³
• Vapor Pressure: 0.000429mmHg at 25°C
• Refractive Index: 1.53
• CAS DataBase Reference: 2-(4-Allyloxy-phenoxymethyl)-oxirane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Allyloxy-phenoxymethyl)-oxirane(52210-93-2)
• EPA Substance Registry System: 2-(4-Allyloxy-phenoxymethyl)-oxirane(52210-93-2)

Safety Data

• Hazardous Substances Data: 52210-93-2(Hazardous Substances Data)

Usage

General Description

2-(4-Allyloxy-phenoxymethyl)-oxirane, also known as glycidyl allyl ether, is a chemical compound with the molecular formula C12H14O3. It is a colorless liquid with a faint, pleasant odor, and is commonly used as a monomer in the production of polymers such as epoxy resins. Glycidyl allyl ether is also used as a crosslinking agent in the manufacture of adhesives and coatings, and as a modifier in the synthesis of specialty chemicals. However, it is important to handle this compound with care, as it is considered to be a skin and respiratory irritant, and exposure to high concentrations can cause adverse health effects.

InChI:InChI=1/C12H14O3/c1-2-7-13-10-3-5-11(6-4-10)14-8-12-9-15-12/h2-6,12H,1,7-9H2

Upstream product

• 123-31-9 hydroquinone 
• 6411-34-3 4-allyloxyphenol 
• 106-89-8 epichlorohydrin 
• 93-59-4 Perbenzoic acid 
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• 37592-20-4 1,4-bis(allyloxy)benzene 

Relevant articles and documents

Development of β-amino alcohol derivatives that inhibit toll-like receptor 4 mediated inflammatory response as potential antiseptics

Toll-like receptor 4 (TLR4) induced proinflammatory signaling has been directly implicated in severe sepsis and represents an attractive therapeutic target. Herein, we report our investigations into the structure-activity relationship and preliminary drug metabolism/pharmacokinetics study of β-amino alcohol derivatives that inhibit the TLR4 signaling pathway. Lead compounds were identified from in vitro cellular examination with micromolar potency for their inhibitory effects on TLR4 signaling and subsequently assessed for their ability to suppress the TLR4-induced inflammatory response in an ex vivo whole blood model. In addition, the toxicology, specificity, solubility, brain-blood barrier permeability, and drug metabolism of several compounds were evaluated. Although further optimizations are needed, our findings lay the groundwork for the future drug development of this class of small molecule agents for the treatment of severe sepsis.