52249-83-9

Basic information

• Product Name: 1-(benzyloxy)-2,3-dimethoxybenzene
• Synonyms: 1-(benzyloxy)-2,3-dimethoxybenzene
• CAS NO: 52249-83-9
• Molecular Weight: 244.29
• Mol File: 52249-83-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-(benzyloxy)-2,3-dimethoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(benzyloxy)-2,3-dimethoxybenzene(52249-83-9)
• EPA Substance Registry System: 1-(benzyloxy)-2,3-dimethoxybenzene(52249-83-9)

Safety Data

• Hazardous Substances Data: 52249-83-9(Hazardous Substances Data)

Upstream product

• 87-66-1 2-hydroxyresorcinol 
• 5150-42-5 2,3-dimethoxyphenol 
• 100-39-0 benzyl bromide 
• 100-44-7 benzyl chloride 
• 103215-00-5 4-(benzyloxy)-2-ethoxybenzo[d][1,3]dioxole 
• 103214-99-9 2-ethoxy4-hydroxy-1,3-benzodioxol 
• 52800-47-2 3-(benzyloxy)benzene-1,2-diol 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 5150-42-5 2,3-dimethoxyphenol 
• 3117-02-0 2,3-dimethoxy-1,4-benzoquinone 
• 19587-73-6 2.3-Dimethoxy-4-benzyloxy-benzylalkohol 
• 69471-04-1 4-benzyloxy-2,3-dimethoxybenzaldehyde 
• 913985-89-4 N-[2-(4-benzyloxy-2,3-dimethoxy-phenyl)-ethyl]-acetamide 
• 770686-91-4 4-benzyloxy-2,3-dimethoxyphenethylamine 
• 913985-88-3 4-bromo-2,3-dimethoxy-1-benzyloxybenzene 

Relevant articles and documents

Exploring the Reactivity of α-Lithiated Aryl Benzyl Ethers: Inhibition of the [1,2]-Wittig Rearrangement and the Mechanistic Proposal Revisited

By carefully controlling the reaction temperature, treatment of aryl benzyl ethers with tBuLi selectively leads to α-lithiation, generating stable organolithiums that can be directly trapped with a variety of selected electrophiles, before they can undergo the expected [1,2]-Wittig rearrangement. This rearrangement has been deeply studied, both experimentally and computationally, with aryl α-lithiated benzyl ethers bearing different substituents at the aryl ring. The obtained results support the competence of a concerted anionic intramolecular addition/elimination sequence and a radical dissociation/recombination sequence for explaining the tendency of migration for aryl groups. The more favored rearrangements are found for substrates with electron-poor aryl groups that favor the anionic pathway.

SUBSTITUTED 2-ANILINOPYRIMIDINES USEFUL AS PROTEIN KINASE INHIBITORS

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