522616-89-3

Basic information

• Product Name: [(2,2-diphenyl-1,3-dioxolan-4-yl)methyl]-2-phenoxyethylamine
• Synonyms: [(2,2-diphenyl-1,3-dioxolan-4-yl)methyl]-2-phenoxyethylamine
• CAS NO: 522616-89-3
• Molecular Weight: 375.467
• Mol File: 522616-89-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [(2,2-diphenyl-1,3-dioxolan-4-yl)methyl]-2-phenoxyethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: [(2,2-diphenyl-1,3-dioxolan-4-yl)methyl]-2-phenoxyethylamine(522616-89-3)
• EPA Substance Registry System: [(2,2-diphenyl-1,3-dioxolan-4-yl)methyl]-2-phenoxyethylamine(522616-89-3)

Safety Data

• Hazardous Substances Data: 522616-89-3(Hazardous Substances Data)

Upstream product

• 108-95-2 phenol 
• 22195-38-6 4--2,2-diphenyl-1,3-dioxolane 
• 1758-46-9 2-phenoxyethanamine 
• 621-88-5 phenoxyacetamide 
• 119-61-9 benzophenone 

Downstream Products

• 522616-94-0 (2,2-diphenyl[1,3]dioxolan-4-ylmethyl)methyl(2-phenoxyethyl)amine 
• 522616-93-9 (2,2-diphenyl[1,3]dioxolan-4-ylmethyl)(2-phenoxyethyl)carbamic acid ethyl ester 

Relevant articles and documents

1,3-Dioxolane-based ligands as a novel class of α1-adrenoceptor antagonists

1,3-Dioxolane-based compounds (2-14) were synthesized, and the pharmacological profiles at α1-adrenoceptor subtypes were assessed by functional experiments in isolated rat vas deferens (α1A), spleen (α1B), and aorta (α1D). Compound 9, with a pA2 of 7.53, 7.36, and 8.65 at α1A, α1B, and α1D, respectively, is the most potent antagonist of the series, while compound 10 with a pA2 of 8.37 at α1D subtype and selectivity ratios of 162 (α1D/α1A) and 324 (α1D/α1B) is the most selective. Binding assays in CHO cell membranes expressing human cloned α1-adrenoceptor subtypes confirm the pharmacological profiles derived from functional experiments, although the selectivity values are somewhat lower. Therefore, it is concluded that 1,3-dioxolane-based ligands are a new class of α1-adrenoceptor antagonists.