52273-79-7

Basic information

• Product Name: 2-(3-Aminophenyl)acetic acid ethyl ester
• Synonyms: (3-Aminophenyl)acetic acid ethyl ester;2-(3-Aminophenyl)acetic acid ethyl ester;Ethyl 3-aminophenylacetate;Ethyl 2-(3-aminophenyl)acetate;3-Amino-benzeneacetic acid ethyl ester
• CAS NO: 52273-79-7
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.22
• Mol File: 52273-79-7.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2-(3-Aminophenyl)acetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-Aminophenyl)acetic acid ethyl ester(52273-79-7)
• EPA Substance Registry System: 2-(3-Aminophenyl)acetic acid ethyl ester(52273-79-7)

Safety Data

• Hazardous Substances Data: 52273-79-7(Hazardous Substances Data)

Usage

Description

2-(3-Aminophenyl)acetic acid ethyl ester, also known as ethyl 2-(3-aminophenyl)acetate, is a chemical compound with the molecular formula C10H13NO2. It is an ester derivative of 2-(3-aminophenyl)acetic acid, known for its potential medical applications and commonly used in organic synthesis and pharmaceutical research.

Uses

Used in Pharmaceutical Research:
2-(3-Aminophenyl)acetic acid ethyl ester is used as a chemical intermediate for the synthesis of pharmaceutical drugs, contributing to the development of new medications.
Used in Organic Synthesis:
In the field of organic synthesis, 2-(3-Aminophenyl)acetic acid ethyl ester is used as a reagent to facilitate the production of other compounds, playing a crucial role in chemical reactions.
Used in Research Studies:
2-(3-Aminophenyl)acetic acid ethyl ester is utilized in research to study its pharmacological properties and explore its potential therapeutic uses, aiding in the advancement of medical knowledge.

Upstream product

• 64-17-5 ethanol 
• 14338-36-4 3-amino phenylacetic acid 
• 408507-75-5 N-(3-cyanomethyl-phenyl)-acetamide 
• 14318-64-0 ethyl (3-nitrophenyI)acetate 
• 6329-95-9 benzoyloxy-(3-nitro-phenyl)-acetic acid ethyl ester 
• 497-19-8 sodium carbonate 
• 99-05-8 meta-aminobenzoic acid 
• 1877-73-2 3-nitro-benzeneacetic acid 

Downstream Products

• 14338-36-4 3-amino phenylacetic acid 
• 52273-77-5 2-(3-aminophenyl)ethan-1-ol 
• 875629-49-5 [3-(4-bromo-2-fluoro-benzylamino)-phenyl]-acetic acid ethyl ester 
• 929519-99-3 C₂₁H₂₂Cl₂N₂O₅S 
• 875629-55-3 [3-(4-bromo-2-fluoro-benzylamino)-phenyl]-acetic acid 
• 400648-51-3 ethyl 2-(3-aminophenyl)-3-(4-nitrophenyl)propionate 

Relevant articles and documents

Hapten design and monoclonal antibody to fluoroacetamide, a small and highly toxic chemical

Fluoroacetamide (FAM) is a small (77 Da) and highly toxic chemical, formerly used as a rodenticide and potentially as a poison by terrorists. Poisoning with FAM has occurred in humans, but few reliably rapid detection methods and antidotes have been reported. Therefore, producing a specific antibody to FAM is not only critical for the development of a fast diagnostic but also a potential treatment. However, achieving this goal is a great challenge, mainly due to the very low molecular weight of FAM. Here, we design two groups of FAM haptens for the first time, maximally exposing the fluorine or amino groups, with the aid of linear aliphatic or phenyl-contained spacer arms. Interestingly, whereas the hapten with fluorine at the far end of the hapten did not induce an antibody response to FAM, the hapten with an amino group at the far end and phenyl-contained spacer arm triggered a significantly specific antibody response. Finally, a monoclonal antibody (mAb) named 5D11 was successfully obtained with an IC50 value of 97 μg mL?1 and negligible cross-reactivities to the other nine functional and structural analogs.

SYMMETRICAL TRIS-ARYL-AMIDE DERIVATIVES AND THEIR USE AS ANTI-HEPARANASE

The present invention relates to tris-aryl-amide derivatives having an anti-heparanase activity, in particular it relates to ureido/thioureido/ether tris-aryl-amide derivatives of formula The invention also relates to the use of such compounds as a medica

BIPHENYL-4-YL-SULFONIC ACID ARYLAMIDES AND THEIR USE AS THERAPEUTIC AGENTS

The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl sulfonamides and related compounds (collectively referred to herein as "BPSAAA compounds"), as described herein, and including, for example, biphenyl-4-sulfonic acid (hydroxyalkyl-phenyl)-amides and related compounds. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, in treatment and/or prevention, for example, of inflammation and/or joint destruction and/or bone loss; of disorders mediated by excessive and/or inappropriate and/or prolonged activation of the immune system; of, inflammatory and autoimmune disorders, for example, rheumatoid arthritis, psoriasis, psoriatic arthritis, chronic obstructive pulmonary disease (COPD), atherosclerosis, inflammatory bowel disease, ankylosing spondylitis, and the like; of disorders associated with bone loss, such as bone loss associated with excessive osteoclast activation in rheumatoid arthritis, osteoporosis, cancer associated bone disease, Paget's disease and the like.