52304-61-7

Basic information

• Product Name: 2,3-PYRAZINEDICARBONYL DICHLORIDE-
• Synonyms: 2,3-PYRAZINEDICARBONYL DICHLORIDE-;pyrazine-2,3-dicarbonyl dichloride
• CAS NO: 52304-61-7
• Molecular Formula: C₆H₂Cl₂N₂O₂
• Molecular Weight: 205
• Mol File: 52304-61-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 300.4±37.0 °C(Predicted)
• Appearance: /
• Density: 1.592±0.06 g/cm3(Predicted)
• PKA: -4.16±0.10(Predicted)
• CAS DataBase Reference: 2,3-PYRAZINEDICARBONYL DICHLORIDE-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-PYRAZINEDICARBONYL DICHLORIDE-(52304-61-7)
• EPA Substance Registry System: 2,3-PYRAZINEDICARBONYL DICHLORIDE-(52304-61-7)

Safety Data

• Hazardous Substances Data: 52304-61-7(Hazardous Substances Data)

Usage

General Description

2,3-Pyrazinedicarbonyl dichloride is a chemical compound with the molecular formula C6H2Cl2N2O2. It is a yellow solid that is soluble in organic solvents and is primarily used as a reagent in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. 2,3-PYRAZINEDICARBONYL DICHLORIDE- is a highly reactive and versatile building block, capable of undergoing a variety of chemical reactions to create new compounds with diverse properties. It is a powerful acylating agent and is often employed in the synthesis of complex organic molecules. However, it is important to handle this compound with caution, as it is corrosive and can cause skin and eye irritation upon contact.

Upstream product

• 89-01-0 2,3-dicarboxypyrazine 

Downstream Products

• 106943-47-9 2-Chlorformyl-N-cyclohexyl-3-pyrazinylglyoxylsaeure-imidchlorid 
• 99886-20-1 7-Cyclohexyl-6,7-dihydro-6-phenyliminopyrazino<2,3-c>pyridin-5,8-dion 

Relevant articles and documents

PRODRUGS BASED ON GEMCITABINE STRUCTURE AS WELL AS SYNTHETIC METHOD AND APPLICATION THEREOF

Prodrugs based on gemcitabine structure shown in formula (I) as well as their synthetic method and application are disclosed in the present invention, wherein the definitions for the groups of a, b, c, d, E, Z and V are described in the specification. By modifying the N4 group, the solubility, the bioavailability and the organ specificity of the prodrugs are improved. Therefore, the fast metabolism problem is overcome for the produced prodrugs compounds. Intestinal toxicity induced by gemcitabine is decreased. Thereby, the prodrugs can be delivered by oral administration in clinics and further improve their anti-tumor, anti-cancer, anti-infection and diffusion preventing capability, and can also specifically act on liver or colon. The synthetic method is simple and adapted to industrial production.

Acetic anhydride mediated condensation of aromatic o-diacid dichlorides with benzimidazoles to provide electro-reducible p-dione adducts

Acetic anhydride mediates a facile and rapid condensation of benzimidazole with aromatic o-diacid dichlorides to precipitate p-dione adducts in excellent yields. Condensation with pyridine-3,4-dicarbonyl dichloride produced a 1:1 mixture of isomeric p-diones. The X-ray crystal structure of one of the latter isomers revealed unusual high density, and inter-layer separation similar to graphite. Cyclic voltammetry demonstrated that p-dione is capable of two consecutive one-electron-reductions with formal potentials influenced by the fused (hetero)aromatic and substituent effects.

Grignard Reactions on Ortho Dicarboxylic Arene Derivatives. Synthesis of 1,3-Dithienylisothianaphthene Compounds

1,3-Dithienylisothianaphthene (10a) is obtained through ring closure of 1,2-dithienoylbenzene (7a). The synthesis of 7a has been accomplished based on a Grignard reaction by adding 2-thiophene-magnesium bromide to 1,2-di(S-(2-pyridinyl)) benzenedithioate (6b) to obtain 7a in a yield of 95%. The use of 6b avoids the formation of the corresponding 3,3-dithienyl-3H-isobenzofuran-1(3H)-one (dithienylphthalide, 8). The same procedure is applied to obtain 1,3-dithienyl-4,5,6,7-tetradeuterioisothianaphthene (10b) and 1,3-dithienyl-4,5,6,7-tetrafluoroisothianaphthene (10c). The synthesis of the 2,3-dithienoylpyridine (12a), 3,4-dithienoylpyridine (12b), and 2,3-dithienoylpyrazine (12c) however fails. The presence of nitrogen in the central ring system influences the result of the Grignard reaction. Possibly the free electron pair of the nitrogen interferes with the formation of a stable six-membered ring intermediate which is essential for the diketone formation.