5236-64-6Relevant articles and documents
SYNTHESIS OF REGIOSPECIFICALLY SUBSTITUTED PYRIMIDYL DERIVATIVES AND THEIR INCORPORATION INTO PENEMS
Capraro, Hans-Georg,Lang, Marc,Schneider, Peter
, p. 643 - 652 (2007/10/02)
Syntheses of regiospecifically substituted pyrimidines are described.Depending on the reaction conditions, N1- or N3-substituted pyrimidines are obtained.It has been shown that substitution on uracil under Mitsunobu conditions yields N1-substituted products.Incorporation of these derivatives into the penem nucleus gives penem antibiotics with extremely long half-lives.