52377-70-5

Basic information

• Product Name: 2-AMINO-5-NITROBENZOHYDRAZIDE
• Synonyms: AURORA KA-5371;2-AMINO-5-NITROBENZOHYDRAZIDE
• CAS NO: 52377-70-5
• Molecular Formula: C₇H₈N₄O₃
• Molecular Weight: 196.16
• Mol File: 52377-70-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.496g/cm³
• Refractive Index: 1.68
• CAS DataBase Reference: 2-AMINO-5-NITROBENZOHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-NITROBENZOHYDRAZIDE(52377-70-5)
• EPA Substance Registry System: 2-AMINO-5-NITROBENZOHYDRAZIDE(52377-70-5)

Safety Data

• Hazardous Substances Data: 52377-70-5(Hazardous Substances Data)

Usage

Properties of 2-AMINO-5-NITROBENZOHYDRAZIDE

Chemical compound: nitroaromatic derivative
Molecular formula: C7H7N5O3
Hazardous material

Specific content of 2-AMINO-5-NITROBENZOHYDRAZIDE

Commonly used as a reagent for the determination of copper
Used in the synthesis of various pharmaceuticals and other organic compounds
Utilized in the production of dyes and other chemical products
Proper safety precautions should be taken when handling and storing this compound

InChI:InChI=1/C7H8N4O3/c8-6-2-1-4(11(13)14)3-5(6)7(12)10-9/h1-3H,8-9H2,(H,10,12)

Upstream product

• 3816-62-4 5-nitroanthranilic acid methyl ester 
• 4693-02-1 6-nitroisatoic anhydride 
• 616-79-5 2-amino-5-nitro-benzoic acid 
• 2516-96-3 2-chloro-5-nitrobenzoic acid 
• 6307-82-0 2-chloro-5-nitro-benzoic acid methyl ester 

Downstream Products

• 77423-10-0 2,5-diaminobenzoic acid hydrazide 
• 90886-86-5 3-Amino-2-methyl-6-nitro-4(3H)-quinazolinone 
• 96134-77-9 2-Amino-5-nitrobenzoic Acid (1-Ethoxyethylidene)hydrazide 
• 96134-78-0 N-<2-Methyl-5-nitro-4-oxo-3(4H)-quinazolinyl>ethanimidic Acid 

Relevant articles and documents

Acylhydrazone compounds with anti-tumor activity as well as preparation method and application of acylhydrazone compounds

The invention belongs to the technical field of medicinal chemistry, and in particular relates to acylhydrazone compounds with anti-tumor activity as well as a preparation method and application of the acylhydrazone compounds. The structures of the acylhydrazone compounds are as shown in a general formula (I) shown in the description, wherein R and R' are independently selected from any one or more of halogen, amino, cyano, alkoxy, 3,4-methylenedioxy, nitro, phenyl or substituted phenyl, and R and R' substituents are mono-substituted, disubstituted or tri-substituted. The preparation method issimple; biological activity test results of the compounds show that the compounds have a very good inhibitory effect on histone methyltransferase SET7, and have good application prospect in the development of anti-tumor aspects.

The Chemistry of 2-Aminobenzoyl Hydrazides. 1. Effects of Orthoester Substituents on the Mode of Cyclization

Treatment of substituted 2-aminobenzoyl hydrazides with orthoesters has been found to yield different products depending upon the type of orthoester employed.Equimolar quantities of orthoester and hydrazide yield 3-amino-4(3H)-quinazolinones, whereas utilization of a two-fold excess (or greater) of orthoester yields, in some cases, 3,4-dihydro-5H-1,3,4-benzotriazepin-5-ones as minor products in addition to N-imidate esters as major products.Treatment of hydrazides with trimethyl orthobenzoate yields substituted 5-(2-aminophenyl)-1,3,4-oxadiazoles and 3,4-dihydro-5H-1,3,4-benzotriazepin-5-ones.The steric bulk of the phenyl group in trimethyl orthobenzoate effects the formation of adduct at the β-nitrogen of the hydrazide which cyclized to the oxadiazole and benzotriazepinone products.In the aliphatic orthoester series, the formation of adduct to the aromatic amino group appears to be favored which gives rise to quinazolinone and benzotriazepinone products.

Pyrazoloquinazolin-9-ones: A New Series of Antiallergic Agents

A new series of antiallergic agents, pyrazoloquinazolin-9-ones, was synthesized and evaluated for inhibitory effects in the rat reaginic passive cutaneous anaphylaxis (PCA) screen.Several analogues were found to be more potent than cromolyn sodium intravenously.Structure-activity relationships are discussed.One of the compounds, 4,9-dihydro-5-methoxy-9-oxopyrazoloquinazoline-2-carboxylic acid (36), was found to be approximately 250 times more potent than cromolyn sodium intravenously.