52464-53-6

Basic information

• Product Name: (2-sec-butoxyphenyl)amine(SALTDATA: FREE)
• Synonyms: (2-sec-butoxyphenyl)amine(SALTDATA: FREE);(2-sec-butoxyphenyl)amine
• CAS NO: 52464-53-6
• Molecular Formula: C₁₀H₁₅NO
• Molecular Weight: 165.2322
• Mol File: 52464-53-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 259.7°C at 760 mmHg
• Flash Point: 108.7°C
• Appearance: /
• Density: 0.997g/cm³
• Vapor Pressure: 0.0128mmHg at 25°C
• Refractive Index: 1.528
• CAS DataBase Reference: (2-sec-butoxyphenyl)amine(SALTDATA: FREE)(CAS DataBase Reference)
• NIST Chemistry Reference: (2-sec-butoxyphenyl)amine(SALTDATA: FREE)(52464-53-6)
• EPA Substance Registry System: (2-sec-butoxyphenyl)amine(SALTDATA: FREE)(52464-53-6)

Safety Data

• Hazardous Substances Data: 52464-53-6(Hazardous Substances Data)

Usage

Description

(2-sec-butoxyphenyl)amine(SALTDATA: FREE) is a chemical compound that is commonly used in the manufacture of pharmaceuticals and agricultural products. It is classified as a monoamine and is commonly used as an intermediate in the production of various organic compounds. It is a clear, colorless liquid with a faint odor and is soluble in organic solvents.

Uses

Used in Pharmaceutical Industry:
(2-sec-butoxyphenyl)amine(SALTDATA: FREE) is used as an intermediate in the production of various pharmaceutical compounds for its ability to facilitate the synthesis of organic compounds.
Used in Agricultural Industry:
(2-sec-butoxyphenyl)amine(SALTDATA: FREE) is used in the manufacture of agricultural products for its role as an intermediate in the production of various organic compounds.
Used as a Free Radical Scavenger:
(2-sec-butoxyphenyl)amine(SALTDATA: FREE) is used as a free radical scavenger in a variety of applications for its ability to neutralize free radicals and protect against oxidative damage.
Safety Precautions:
It should be handled with care as it can cause irritation to the skin and eyes, and may be harmful if ingested or inhaled.

InChI:InChI=1/C10H15NO/c1-3-8(2)12-10-7-5-4-6-9(10)11/h4-8H,3,11H2,1-2H3

Upstream product

• 513-48-4 2-butyl iodide 
• 1624-53-9 2-(benzylideneamino)phenol 
• 78-76-2 s-butyl bromide 
• 95-55-6 2-amino-phenol 

Downstream Products

• 114559-78-3 1-(2-sec-Butoxy-phenyl)-3-((1R,3R,5S)-8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-urea 

Relevant articles and documents

Investigation of hydro-lipophilic properties of n-alkoxyphenylhydroxynaphthalenecarboxamides ?

The evaluation of the lipophilic characteristics of biologically active agents is indispensable for the rational design of ADMET-tailored structure–activity models. N-Alkoxy-3-hydroxynaphthalene-2-carboxanilides, N-alkoxy-1-hydroxynaphthalene-2-carboxanilides, and N-alkoxy-2-hydroxynaphthalene-1-carboxanilides were recently reported as a series of compounds with antimycobacterial, antibacterial, and herbicidal activity. As it was found that the lipophilicity of these biologically active agents determines their activity, the hydro-lipophilic properties of all three series were investigated in this study. All 57 anilides were analyzed using the reversed-phase high-performance liquid chromatography method for the measurement of lipophilicity. The procedure was performed under isocratic conditions with methanol as an organic modifier in the mobile phase using an end-capped non-polar C18 stationary reversed-phase column. In the present study, a range of software lipophilicity predictors for the estimation of clogP values of a set of N-alkoxyphenylhydroxynaphthalenecarboxamides was employed and subsequently cross-compared with experimental parameters. Thus, the empirical values of lipophilicity (logk) and the distributive parameters (π) were compared with the corresponding in silico characteristics that were calculated using alternative methods for deducing the lipophilic features. To scrutinize (dis)similarities between the derivatives, a PCA procedure was applied to visualize the major differences in the performance of molecules with respect to their lipophilic profile, molecular weight, and violations of Lipinski’s Rule of Five.

Selective alkylation of aminophenols

O-or N-Alkylated derivatives of aminophenols are important synthetic intermediates in organic synthesis. A series of aminophenols were selectively alkylated on their hydroxyl group in good yields via benzaldehyde protection of the amino group, subsequent alkylation, and hydrolysis; or on their amino group via imination and following reduction. ARKAT USA, Inc.

THIENOPYRIMIDINES FOR PHARMACEUTICAL COMPOSITIONS

The present invention relates to novel pharmaceutical compositions of general formula (I) comprising thienopyrimidine compounds. Moreover, the present invention relates to the use of the thienopyrimidine compounds of the invention for the production of pharmaceutical compositions for the prophylaxis and/or treatment of diseases which can be influenced by the inhibition of the kinase activity of Mnk1 and/or Mnk2 (Mnk2a or Mnk2b) and/or variants thereof.