5247-25-6

Basic information

• Product Name: 2-(3-nitrophenyl)acetic acid amide
• Synonyms: 2-(3-nitrophenyl)acetic acid amide
• CAS NO: 5247-25-6
• Molecular Weight: 180.163
• Mol File: 5247-25-6.mol
• Article Data: 11

Chemical Properties

• Melting Point: 134-136 °C
• Boiling Point: 428.0±28.0 °C(Predicted)
• Density: 1.335±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-(3-nitrophenyl)acetic acid amide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-nitrophenyl)acetic acid amide(5247-25-6)
• EPA Substance Registry System: 2-(3-nitrophenyl)acetic acid amide(5247-25-6)

Safety Data

• Hazardous Substances Data: 5247-25-6(Hazardous Substances Data)

Usage

Structure

A derivative of 2-(3-nitrophenyl)acetic acid with an amide functional group added

Synthesis

Typically synthesized for use in chemical research and pharmaceutical development

Potential applications

Possible use in the synthesis of new drugs and materials due to its structural properties and functional groups

Use as a precursor

May be used as a precursor or intermediate in organic synthesis

Subject of interest

Of interest to researchers in the fields of chemistry and pharmaceuticals due to its properties and potential uses.

Upstream product

• 38411-41-5 (3-nitrophenyl)acetyl chloride 
• 10268-12-9 methyl 3-nitrophenylacetate 
• 5247-23-4 3-Nitro-benzotricyanid 
• 1877-73-2 3-nitro-benzeneacetic acid 
• 103-81-1 Benzeneacetamide 

Downstream Products

• 725686-30-6 1-{3-tert-butyl-1-[3-(carbamoylmethyl)phenyl)-1H-pyrazol-5-yl}-3-(naphthalene-1-yl)urea 
• 725686-31-7 1-{3-tert-butyl-1-[3-(carbamoylmethyl)phenyl)-1H-pyrazol-5-yl}-3-(4-chlorophenyl)urea 
• 725686-42-0 3-tert-butyl-1-[3-(2-aminoethyl)phenyl]-1H-pyrazol-5-amine 
• 19008-62-9 1-(3-nitrophenyl)-2-ethanamine hydrochloride 
• 142273-34-5 2-(3-nitrophenyl)ethanethioamide 
• 621-50-1 (3-nitrophenyl)acetonitrile 
• 129743-47-1 2-(3-aminophenyl)acetic acid amide 
• 4623-24-9 2-(3-aminophenyl)acetonitrile 
• 264224-10-4 3-chloro-4-(3-nitrophenyl)-1H-pyrrole-2,5-dione 
• 868697-63-6 C₃₇H₃₉N₅O₈ 

Relevant articles and documents

ANTI-HUMAN VISTA ANTIBODIES AND USE THEREOF

The invention provides anti-VISTA antibody drug conjugates which may be used for targeted delivery of anti-inflammatory agents such as steroids to immune cells, e.g., myeloid cells. The invention also provides methods of using anti-VISTA antibody drug conjugates in the treatment of inflammatory and/or autoimmune conditions and/or for alleviating the toxicity of anti-inflammatory agents such as steroids.

Anti-inflammatory medicaments

Novel compounds and methods of using those compounds for the treatment of inflammatory conditions are provided. In a preferred embodiment, modulation of the activation state of p38 kinase protein comprises the step of contacting the kinase protein with the novel compounds.

MODULATION OF PROTEIN FUNCTIONALITIES

New methods for the rational identification of molecules capable of interacting with specific naturally occurring proteins are provided, in order to yield new pharmacologically important compounds and treatment modalities. Broadly, the method comprises the steps of identifying a switch control ligand forming a part of a particular protein of interest, and also identifying a complemental switch control pocket forming a part of the protein and which interacts with said switch control ligand. The ligand interacts in vivo with the pocket to regulate the conformation and biological activity of the protein such that the protein assumes a first conformation and a first biological activity upon the ligand-pocket interaction, and assumes a second, different conformation and biological activity in the absence of the ligand-pocket interaction. Next, respective samples of said protein in the first and second conformations are provided, and these are screened against one or more candidate molecules by contacting the molecules and the samples. Thereupon, small molecules which bind with the protein at the region of the pocket may be identified. Novel protein-modulator adducts and methods of altering protein activity are also provided.