524959-64-6

Basic information

• Product Name: 2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)acetonitrile
• Synonyms: 2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)acetonitrile
• CAS NO: 524959-64-6
• Molecular Weight: 198.224
• Mol File: 524959-64-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)acetonitrile(524959-64-6)
• EPA Substance Registry System: 2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)acetonitrile(524959-64-6)

Safety Data

• Hazardous Substances Data: 524959-64-6(Hazardous Substances Data)

Upstream product

• 143-33-9 sodium cyanide 
• 103788-61-0 (5-methyl-2-phenyl-4-oxazolyl)methyl chloride 
• 100-52-7 benzaldehyde 
• 27492-46-2 4,5-dimethyl-2-phenyl-oxazole 3-oxide 
• 151-50-8 potassium cyanide 

Downstream Products

• 1394014-09-5 C₂₅H₂₈N₂O₅ 
• 1394014-10-8 C₂₅H₂₈N₂O₅ 
• 1394014-11-9 C₂₆H₂₈N₂O₅ 
• 1394014-12-0 C₂₆H₂₈N₂O₅ 
• 888707-94-6 C₂₄H₂₆N₂O₅ 
• 888707-96-8 C₂₄H₂₆N₂O₅ 
• 888708-07-4 C₂₅H₂₈N₂O₅ 
• 888708-09-6 C₂₅H₂₈N₂O₅ 
• 1394014-15-3 C₂₆H₂₈N₂O₅ 
• 1394014-16-4 C₂₆H₂₈N₂O₅ 
• 888707-88-8 C₂₅H₂₇FN₂O₅ 
• 888707-63-9 C₂₆H₃₀N₂O₅ 
• 1394014-03-9 C₂₄H₂₅FN₂O₅ 
• 1394014-04-0 C₂₄H₂₅FN₂O₅ 

Relevant articles and documents

Design and synthesis of Oxime ethers of β-oxo-γ-phenylbutanoic acids as PPAR a and -γ dual agonists

Oxime ethers of p-oxo-y-phenylbutanoic acids were prepared to develop more effective PPAR a and y dual agonists. Among them, compound 11k exhibited potent in vitro activities with EC50 of 2.5 nM and 3.3 nM in PPAR a and y, respectively. It showed better g

Design and synthesis of oxime ethers of α-acyl-β-phenylpropanoic acids as PPAR dual agonists

Oxime ethers of α-acyl-β-phenylpropanoic acids were prepared to apply as PPARα and γ dual agonists. Among them, compound 11l proved to exhibit potent in vitro activities with EC50 of 19 and 13 nM in PPARα and γ, respectively. It showed better g

Conversion of human-selective PPARα agonists to human/mouse dual agonists: A molecular modeling analysis

To understand the species selectivity in a series of α-methyl- α-phenoxy carboxylic acid PPARα/γ dual agonists (1-11), structure-based molecular modeling was carried out in the ligand binding pockets of both human and mouse PPARα. This study suggested that interaction of both 4-phenoxy and phenyloxazole substituents of these ligands with F272 and M279 in mouse PPARα leads to the species-specific divergence in ligand binding. Insights obtained in the molecular modeling studies of these key interactions resulted in the ability to convert a human-selective PPARα agonist to a human and mouse dual agonist within the same platform.