52505-45-0

Basic information

• Product Name: 2-sulfanylidene-1H-pyridine-3-carbonitrile
• Synonyms: 2-sulfanylidene-1H-pyridine-3-carbonitrile;1,2-dihydro-2-thioxo-3-Pyridinecarbonitrile;3-Pyridinecarbonitrile, 1,2-dihydro-2-thioxo-;2-Mercapto-3-pyridinecarbonitrile;3-Cyano-2(1H)-pyridinethione;3-Cyano-2-mercaptopyridine;3-Cyanopyridine-2-thiol;NSC 266131
• CAS NO: 52505-45-0
• Molecular Formula: C₆H₄N₂S
• Molecular Weight: 136.178
• Product Categories: Fine Chemicals
• Mol File: 52505-45-0.mol
• Article Data: 16

Chemical Properties

• Melting Point: 248-250°
• Boiling Point: 230℃
• Flash Point: 93℃
• Appearance: /
• Density: 1.32
• Vapor Pressure: 0.0689mmHg at 25°C
• Refractive Index: 1.664
• PKA: 7.73±0.40(Predicted)
• CAS DataBase Reference: 2-sulfanylidene-1H-pyridine-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-sulfanylidene-1H-pyridine-3-carbonitrile(52505-45-0)
• EPA Substance Registry System: 2-sulfanylidene-1H-pyridine-3-carbonitrile(52505-45-0)

Safety Data

• Hazard Codes: T
• Statements: 25-41
• Safety Statements: 26-39-45
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 52505-45-0(Hazardous Substances Data)

Usage

General Description

2-sulfanylidene-1H-pyridine-3-carbonitrile, also known as 3-cyano-2-pyridinethiol, is a chemical compound with the molecular formula C6H3N3S. It is a heterocyclic compound containing a pyridine ring with a sulfur atom and a cyano group attached to it. 2-sulfanylidene-1H-pyridine-3-carbonitrile is commonly used in organic synthesis and pharmaceutical research as a building block for the synthesis of various bioactive molecules. It has been reported to exhibit potential anti-inflammatory and antioxidant properties, making it of interest for pharmacological applications. Additionally, 2-sulfanylidene-1H-pyridine-3-carbonitrile has been studied for its potential antimicrobial and anti-tumor activities, further highlighting its versatility and potential utility in various fields of chemistry and biology.

InChI:InChI=1/C6H4N2S/c7-4-5-2-1-3-8-6(5)9/h1-3H,(H,8,9)

Upstream product

• 14906-64-0 3-cyanopyridine N-oxide 
• 6602-54-6 2-chloro-3-pyridinecarbonitrile 
• 111042-81-0 2-(2-Carbomethoxyethylthio)-3-cyanopyridine 
• 17356-08-0 thiourea 
• 4767-80-0 isothiazolo<4,5-b>pyridine 
• 50-00-0 formaldehyd 
• 7357-70-2 Cyanothioacetamide 
• 75-07-0 acetaldehyde 

Downstream Products

• 52505-47-2 3-aminothieno[2,3-b]pyridine-2-carbonitrile 
• 52505-46-1 ethyl 3-aminothieno[2,3-b]pyridine-2-carboxylate 
• 52505-41-6 2-acetyl-3-aminopyrido[2,3-b]thiophene 
• 52505-48-3 3-amino-2-benzoylthieno [2,3-b] pyridine 
• 52505-49-4 3-amino-2-nitrothieno<2,3-b>pyridine 
• 56891-64-6 3-aminoisothiazolo(5,4-b)pyridine 
• 50596-67-3 1,2-dihydro-2-thioxo-3-pyridinecarboxamide 
• 26579-54-4 3-aminothieno[2,3-b]pyridine 
• 7254-34-4 2-methoxy-3-cyanopyridine 
• 145325-39-9 2-benzoyl-3-ethoxymethyleneamino-thieno<2,3-b>pyridine 
• 91870-91-6 1H-2-methylimidazo<3',4':4,5>thieno<2,3-b>pyridine 
• 58327-82-5 2-(4-chloro-benzylidene)-thieno[2,3-b]pyridin-3-one 
• 58327-75-6 3-aminothieno[2,3-b]pyridine-2-carboxylic acid 
• 540492-90-8 3-bromoisothiazolo[5,4-b]pyridine 

Relevant articles and documents

Polycyclic N-heterocyclic compounds. Part 84: Reaction of N-(pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-yl)amidines or N-(pyrido[2',3':4,5]furo[3,2-d]pyrimidin-4-yl)amidines with hydroxylamine hydrochloride

The reactions of nine N-(pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-yl)amidines (3) with hydroxylamine hydrochloride produced new cyclization products. These were formed via ring cleavage of the pyrimidine component followed by a 1,2,4-oxadiazole-forming r

GLUCOSE UPTAKE INHIBITORS AND USES THEREOF

The present invention relates to novel compounds that modulate cellular glucose uptake by affecting various targets, including, but not limited to those related to glycolysis and known transporters/co-transporters of the GLUT family. The compounds according to the invention are useful for treating cancer such as: neuroendrocrine neoplasms, gastrointestinal stromal tumors (GIST), renal cell carcinoma, paraganglioma, pheochromocytoma, pituitary adenoma, colorectal cancer, lung cancer, gastric cancer, pancreatic cancer sarcoma, head and neck cancer, melanoma, ovarian cancer and other cancers that rely on high levels of glycolysis for survival and proliferation; as well as in treating of autoimmune diseases, inflammation, infectious diseases, and metabolic diseases.

1,2-BENZISOSELENAZOL-3(2H)-ONE AND 1,2-BENZISOTHIAZOL-3(2H)-ONE DERIVATIVES AS BETA-LACTAM ANTIBIOTIC ADJUVANTS

Provided herein are compositions and methods useful in the treatment of beta-lactam antibiotic resistant bacteria.