52505-58-5Relevant articles and documents
Discovery and SAR of a novel series of potent, CNS penetrant M4PAMs based on a non-enolizable ketone core: Challenges in disposition
Wood, Michael R.,Noetzel, Meredith J.,Tarr, James C.,Rodriguez, Alice L.,Lamsal, Atin,Chang, Sichen,Foster, Jarrett J.,Smith, Emery,Chase, Peter,Hodder, Peter S.,Engers, Darren W.,Niswender, Colleen M.,Brandon, Nicholas J.,Wood, Michael W.,Duggan, Mark E.,Conn, P. Jeffrey,Bridges, Thomas M.,Lindsley, Craig W.
, p. 4282 - 4286 (2016)
This Letter describes the chemical optimization of a novel series of M4PAMs based on a non-enolizable ketone core, identified from an MLPCN functional high-throughput screen. The HTS hit was potent, selective and CNS penetrant; however, the com
Synthesis and properties of substituted isoxazolo[3′,4′:4,5]- thieno[2,3-b]pyridines
Vasilin,Kaigorodova,Firgang,Krapivin
, p. 377 - 386 (2007/10/03)
We synthesized derivatives of a novel heterocyclic system, isoxazolo[3′,4′:4,5]thieno[2,3-b]pyridine by sequential conversions in three steps: isomerization of 2-(2-R-ethylthio-2-oxo)-3-pyridyl cyanides obtained by alkylation from substituted 3-cyano-2(1H)-pyridinethiones by α-halomethyl ketones in alkaline medium, to form 3-aminothieno[2,3-b] pyridines; diazotization of the amino group followed by nucleophilic substitution of the diazonium group by an azido group, bypassing the step of isolating the diazonium salts; and thermolysis of the azides formed.
Synthesis of 3 aminothieno [2,3 b]pyridine derivatives II
Guerrera,Siracusa,Tornetta
, p. 21 - 30 (2007/10/05)
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