52528-49-1

Basic information

• Product Name: Spiro[4.5]dec-6-ene-2-carboxylic acid, 6,10-dimethyl-, methyl ester, (2R,5S,10S)-rel-
• CAS NO: 52528-49-1
• Molecular Formula: C14H22O2
• Molecular Weight: 222.327
• Mol File: 52528-49-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Spiro[4.5]dec-6-ene-2-carboxylic acid, 6,10-dimethyl-, methyl ester, (2R,5S,10S)-rel-(CAS DataBase Reference)
• NIST Chemistry Reference: Spiro[4.5]dec-6-ene-2-carboxylic acid, 6,10-dimethyl-, methyl ester, (2R,5S,10S)-rel-(52528-49-1)
• EPA Substance Registry System: Spiro[4.5]dec-6-ene-2-carboxylic acid, 6,10-dimethyl-, methyl ester, (2R,5S,10S)-rel-(52528-49-1)

Safety Data

• Hazardous Substances Data: 52528-49-1(Hazardous Substances Data)

Upstream product

• 79265-79-5 (8S,10S,13R)-7,13-Dimethyl-1,4-dithia-dispiro[4.2.4.2]tetradec-6-en-10-ol 
• 79265-78-4 (2S^*,5S^*,10R^*)-2-hydroxy-6,10-dimethylspiro<4.5>dec-6-en-8-one 
• 51388-76-2 (2S^*,5S^*,10R^*)-6,10-dimethylspiro<4.5>dec-6-en-2-ol 
• 81346-19-2 (5S^*,10R^*)-3-chloro-6,10-dimethylspiro<4.5>deca-2,6-diene-2-carboxylic acid 
• 81346-18-1 (5S^*,10R^*)-3-chloro-6,10-dimethylspiro<4.5>deca-2,6-diene-2-carbaldehyde 
• 18444-84-3 (5S^*,10R^*)-6,10-dimethylspiro<4.5>dec-6-en-2-one 
• 186581-53-3 diazomethane 
• 81346-20-5 (2RS,5R^*,10R^*)-6,10-dimethylspiro<4.5>dec-6-ene-2-carboxylic acid 

Downstream Products

• 1460-73-7 (±)-agarospirol 
• 1460-73-7 (2RS,5SR,10SR)-hinesol 
• 59331-07-6 (+/-)-hinesol 
• 1460-73-7 2-[(3R,5R,6R)-6,10-dimethylspiro[4.5]dec-9-en-3-yl]propan-2-ol 

Relevant articles and documents

Connective synthesis of spirovetivanes: Total synthesis of (±)-agarospirol, (±)-hinesol and (±)-α-vetispirene

A concise, connective synthesis of naturally occurring spirovetivanes 1 and 3, in racemic form, is presented. This novel approach involves the efficient assembly of the advanced intermediate 12 through a unique spiroannulation protocol. Wiley-VCH Verlag GmbH & Co. KGaA1 69451 Weinheim, Germany, 2004.