5253-86-1

Basic information

• Product Name: O-benzoyl-N-(3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)propyl)-N-methylhydroxylamine
• Synonyms: O-benzoyl-N-(3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)propyl)-N-methylhydroxylamine
• CAS NO: 5253-86-1
• Molecular Weight: 383.49
• Mol File: 5253-86-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: O-benzoyl-N-(3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)propyl)-N-methylhydroxylamine(CAS DataBase Reference)
• NIST Chemistry Reference: O-benzoyl-N-(3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)propyl)-N-methylhydroxylamine(5253-86-1)
• EPA Substance Registry System: O-benzoyl-N-(3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)propyl)-N-methylhydroxylamine(5253-86-1)

Safety Data

• Hazardous Substances Data: 5253-86-1(Hazardous Substances Data)

Upstream product

• 5253-85-0 N-[3-(10,11-Dihydro-dibenzo[a,d]cyclohepten-5-ylidene)-propyl]-N-methyl-hydroxylamine 
• 98-88-4 benzoyl chloride 
• 894-71-3 nortriptyline hydrochloride 

Relevant articles and documents

Late Stage Functionalization of Secondary Amines via a Cobalt-Catalyzed Electrophilic Amination of Organozinc Reagents

A general preparation of polyfunctional hydroxylamine benzoates from the corresponding secondary amines is reported. This convenient synthesis allows the setup of a late-stage functionalization of various secondary amines, including pharmaceuticals and peptidic derivatives. Thus, a cross-coupling of hydroxylamine benzoates with various alkyl-, aryl-, and heteroaryl-zinc chlorides in the presence of 5 mol % CoCl2 (25 °C, 2 h) provides a range of polyfunctional tertiary amines. This method was used to prepare penfluridol and gepirone.